Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Inflamm Bowel Dis. 2012 Oct;18(10):1982-96. doi: 10.1002/ibd.22934. Epub 2012 Mar 8.
The purpose of this review is to introduce the exciting field of epigenetics and to describe how it could explain the mechanisms by which environmental changes induce pathological gene expression and determine cell phenotype and function in IBD. We outline how epigenetics research in the context of a variety of clinical conditions, but mainly in cancer, has begun to define the role of multiple combinations of modifications to chromatin, diverse families of enzymes, and non-coding RNAs in determining transcriptional outcomes. These findings are applicable to understanding the context-specific events that underlie the expression of genes in diseases like IBD and have the potential to reveal new targets for improved IBD therapy. The current status of epigenetics-based therapies is also summarized.
本次综述旨在介绍令人兴奋的表观遗传学领域，并描述其如何解释环境变化如何诱导 IBD 中病理性基因表达，并决定细胞表型和功能的机制。我们概述了在各种临床情况下（主要是在癌症中）进行的表观遗传学研究，如何开始定义染色质、多种酶家族和非编码 RNA 的多种修饰组合在决定转录结果中的作用。这些发现适用于理解 IBD 等疾病中基因表达的特定于上下文的事件，并有可能揭示改善 IBD 治疗的新靶点。本文还总结了基于表观遗传学的治疗方法的现状。
