Kuppachi Sarat, Kaur Deepkamal, Holanda Danniele G, Thomas Christie P
Department of Internal Medicine , University of Iowa, Carver College of Medicine , Iowa City, IA , USA.
Department of Pathology , University of Iowa, Carver College of Medicine , Iowa City, IA , USA.
Clin Kidney J. 2016 Apr;9(2):310-8. doi: 10.1093/ckj/sfv143. Epub 2015 Dec 30.
BK virus (BKV) is a non-enveloped DNA virus of the polyomaviridae family that causes an interstitial nephritis in immunosuppressed patients. BKV nephropathy is now a leading cause of chronic kidney disease and early allograft failure following kidney transplantation. It is also known to cause renal disease with a progressive decline in kidney function in non-renal solid organ transplant (NRSOT) recipients, although the disease may not be recognized nor its impact appreciated in this patient population. In this report, we review the existing literature to highlight our current understanding of its incidence in NRSOT populations, the approaches to diagnosis and the potential treatment options.
BK病毒（BKV）是多瘤病毒科的一种无包膜DNA病毒，可导致免疫抑制患者发生间质性肾炎。BKV肾病目前是肾移植后慢性肾病和早期移植肾失功的主要原因。已知它也会在非肾实体器官移植（NRSOT）受者中引起肾功能逐渐下降的肾病，尽管在该患者群体中可能未认识到这种疾病及其影响。在本报告中，我们回顾现有文献以突出我们目前对其在NRSOT人群中的发病率、诊断方法和潜在治疗选择的理解。
