Department of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
J Infect Dis. 2012 Sep 15;206(6):875-80. doi: 10.1093/infdis/jis469. Epub 2012 Jul 16.
Polyomavirus reactivation can cause significant morbidity in solid organ transplant recipients, particularly BK virus (BKV) in kidney transplant patients. Less is known about dynamics of John Cunningham virus (JCV) in nonkidney organ transplant patients.
We examined the frequency of urinary shedding of polyomaviruses BKV and JCV and their relationship to creatinine clearance (CrCl) in a longitudinal study of 41 kidney and 33 liver transplant recipients.
Any polyomavirus urinary shedding was more frequent in liver than kidney recipients (64% vs 39%; P= .03). JCV was excreted more frequently by liver than kidney recipients (71% vs 38%), whereas BKV was shed more often by kidney than liver patients (69% vs 52%). Mean JCV loads were significantly higher than those of BKV in both patient groups (P< .0001). Lower mean CrCl values were significantly associated with JCV shedding in both kidney and liver recipients (P< .001).
These findings suggest that BKV and JCV display different patterns of reactivation and shedding in kidney and liver transplant patients and that JCV may have a role in renal dysfunction in some solid organ transplant recipients.
多瘤病毒的激活可导致实体器官移植受者发生严重的发病率，尤其是在肾移植患者中，BK 病毒（BKV）可导致严重的发病率。在非肾器官移植患者中，关于 JC 病毒（JCV）的动态变化知之甚少。
我们对 41 例肾移植患者和 33 例肝移植患者进行了纵向研究，检测了多瘤病毒 BKV 和 JCV 的尿中脱落情况及其与肌酐清除率（CrCl）的关系。
在肝移植受者中，任何多瘤病毒的尿中脱落均比肾移植受者更常见（64%比 39%；P=.03）。与肾移植受者相比，肝移植受者更常排出 JCV（71%比 38%），而肾移植受者更常排出 BKV（69%比 52%）。在两组患者中，JCV 的平均载量均显著高于 BKV（P<.0001）。在肾和肝移植受者中，CrCl 值均与 JCV 的脱落显著相关（P<.001）。
这些发现表明，BKV 和 JCV 在肾和肝移植患者中显示出不同的再激活和脱落模式，JCV 可能在某些实体器官移植受者的肾功能障碍中发挥作用。
