Scadden Jacob Rw, Sharif Adnan, Skordilis Kassi, Borrows Richard
University of Birmingham, Edgbaston, Birmingham B15 2TH, United Kingdom.
Department of Kidney Transplantation, Queen Elizabeth Hospital Birmingham, Birmingham B15 2TH, United Kingdom.
World J Transplant. 2017 Dec 24;7(6):329-338. doi: 10.5500/wjt.v7.i6.329.
BK virus (BKV) is a polyomavirus that is able to cause renal dysfunction in transplanted grafts BK virus-associated nephritis (BKVAN). This condition was mis-diagnosed in the past due to clinical and histopthological similarities with acute rejection. Due to the prevalence of the virus in the population, it is an important pathogen in this context, and so it is important to understand how this virus functions and its' relationship with the pathogenesis of BKVN. Screening for BKV often reveals viruria and/or viremia, which then manifests as BKVN, which can be asymptomatic or result in clinical features namely renal dysfunction. The pathogenesis of BKV infection is still unclear and needs to be further investigated; nevertheless there are a variety of hypotheses that indicate that there are a host of factors that play important roles. Treatments for BKVAN include a reduction in immunosuppression, the use of antiviral therapy or the combination of both treatment options.
BK病毒（BKV）是一种多瘤病毒，能够在移植器官中引发肾功能障碍，即BK病毒相关性肾炎（BKVAN）。由于在临床和组织病理学上与急性排斥反应相似，这种病症在过去曾被误诊。鉴于该病毒在人群中的普遍存在，在这种情况下它是一种重要的病原体，因此了解这种病毒的功能及其与BKVN发病机制的关系非常重要。对BKV的筛查通常会发现病毒尿和/或病毒血症，进而表现为BKVN，其可能无症状，也可能导致肾功能障碍等临床症状。BKV感染的发病机制仍不清楚，需要进一步研究；然而，有多种假说表明有许多因素发挥着重要作用。BKVAN的治疗方法包括减少免疫抑制、使用抗病毒疗法或两者联合使用。
