Jankun Jerzy, Wyganowska-Świątkowska Marzena, Dettlaff Katarzyna, Jelińska Anna, Surdacka Anna, Wątróbska-Świetlikowska Dorota, Skrzypczak-Jankun Ewa
Urology Research Center, Department of Urology, College of Medicine, University of Toledo, Toledo, OH 43614, USA.
Department of Conservative Dentistry and Periodontology, Poznań University of Medical Sciences, 60-812 Poznan, Poland.
Int J Mol Med. 2016 May;37(5):1151-8. doi: 10.3892/ijmm.2016.2524. Epub 2016 Mar 11.
Curcumin has been shown to exert therapeutic or protective effects against a variety of diseases, such as cancer, pulmonary diseases, neurological, liver, metabolic, autoimmune, cardiovascular diseases and numerous other chronic ailments. Over 116 clinical studies on curcumin in humans were registered with the US National Institutes of Health in 2015. However, it is mystifying how curcumin can be so effective in the treatment of many diseases since it has very low water solubility and bioavailability. Furthermore, curcumin is not stable under various conditions; its degradation or condensation into different bioactive compounds may be responsible for its biological activities rather than curcumin itself. In this review, we provide evidence of curcumin degradation and condensation into different compounds which have or may have health benefits themselves. Literature reviews strongly suggest that these molecules contribute to the observed health benefits, rather than curcumin itself.
姜黄素已被证明对多种疾病具有治疗或保护作用，如癌症、肺部疾病、神经疾病、肝脏疾病、代谢疾病、自身免疫性疾病、心血管疾病以及许多其他慢性疾病。2015年，美国国立卫生研究院登记了超过116项关于姜黄素在人体中的临床研究。然而，令人困惑的是，姜黄素的水溶性和生物利用度极低，却为何能在治疗多种疾病方面如此有效。此外，姜黄素在各种条件下都不稳定；其降解或缩合形成不同的生物活性化合物可能是其生物活性的原因，而非姜黄素本身。在本综述中，我们提供了姜黄素降解并缩合形成不同化合物的证据，这些化合物本身具有或可能具有健康益处。文献综述有力地表明，这些分子对所观察到的健康益处有贡献，而非姜黄素本身。
