Zhu Julia, Sanidad Katherine Z, Sukamtoh Elvira, Zhang Guodong
Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
Food Funct. 2017 Mar 22;8(3):907-914. doi: 10.1039/c6fo01770c.
Substantial pre-clinical and human studies have shown that curcumin, a dietary compound from turmeric, has a variety of health-promoting biological activities. A better understanding of the biochemical mechanisms for the health-promoting effects of curcumin could facilitate the development of effective strategies for disease prevention. Recent studies have shown that in aqueous buffer, curcumin rapidly degrades and leads to formation of various degradation products. In this review, we summarized and discussed the biological activities of chemical degradation products of curcumin, including alkaline hydrolysis products (such as ferulic acid, vanillin, ferulaldehyde, and feruloyl methane), and autoxidation products (such as bicyclopentadione). Though many of these degradation products are biologically active, they are substantially less-active compared to curcumin, supporting that chemical degradation has a limited contribution to the biological activities of curcumin.
大量临床前和人体研究表明，姜黄素这种来自姜黄的膳食化合物具有多种促进健康的生物活性。更好地理解姜黄素促进健康作用的生化机制有助于制定有效的疾病预防策略。最近的研究表明，在水性缓冲液中，姜黄素会迅速降解并产生各种降解产物。在这篇综述中，我们总结并讨论了姜黄素化学降解产物的生物活性，包括碱性水解产物（如阿魏酸、香草醛、阿魏醛和阿魏酰甲烷）和自氧化产物（如双环戊二酮）。尽管这些降解产物中的许多都具有生物活性，但与姜黄素相比，它们的活性要低得多，这表明化学降解对姜黄素生物活性的贡献有限。
