RAB GTP酶、自噬与神经退行性变之间新出现的联系。
Emerging nexus between RAB GTPases, autophagy and neurodegeneration.
作者信息
Jain Navodita, Ganesh Subramaniam
机构信息
a Department of Biological Sciences & Bioengineering , Indian Institute of Technology , Kanpur , India.
出版信息
Autophagy. 2016 May 3;12(5):900-4. doi: 10.1080/15548627.2016.1147673. Epub 2016 Mar 17.
Abstract
The RAB class of small GTPases includes the major regulators of intracellular communication, which are involved in vesicle generation through fusion and fission, and vesicular trafficking. RAB proteins also play an imperative role in neuronal maintenance and survival. Recent studies in the field of neurodegeneration have also highlighted the process of autophagy as being essential for neuronal maintenance. Here we review the emerging roles of RAB proteins in regulating macroautophagy and its impact in the context of neurodegenerative diseases.
摘要
小GTP酶的RAB家族包括细胞内通讯的主要调节因子，它们通过融合和裂变参与囊泡生成以及囊泡运输。RAB蛋白在神经元维持和存活中也起着至关重要的作用。神经退行性变领域的最新研究也强调了自噬过程对神经元维持至关重要。在此，我们综述RAB蛋白在调节巨自噬中的新作用及其在神经退行性疾病背景下的影响。
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