Geha R S, Leung D Y
Harvard Medical School, Boston, MA 02115.
Immunodefic Rev. 1989;1(2):155-72.
The Hyper Immunoglobulin E(HIE) Syndrome is a rare disorder of unknown etiology associated with extremely high serum IgE levels, serious recurrent infections and chronic dermatitis. The current paper will review the clinical and laboratory manifestations of the HIE Syndrome and discuss them in relationship to underline immunologic abnormalities found in this syndrome.
高免疫球蛋白E(HIE)综合征是一种病因不明的罕见疾病,与血清IgE水平极高、严重反复感染和慢性皮炎有关。本文将回顾HIE综合征的临床和实验室表现,并结合该综合征中发现的潜在免疫异常进行讨论。