Plata F, Dadaglio G, Chenciner N, Hoffenbach A, Wain-Hobson S, Michel F, Langlade-Demoyen P
Laboratoire de Biologie et d'Immunologie Moléculaires des Rétrovirus, Institut Pasteur, Paris, France.
Immunodefic Rev. 1989;1(3):227-46.
The immune response to HIV in infected humans leads to the production of HIV-specific cytotoxic T lymphocytes (CTL) which circulate in high frequencies. The presence of these CTL and their eventual protective activities have been studied by various laboratories, and correlations have been made with certain immunopathological manifestations of HIV infections. It seems probable that HIV-immune CTL participate in the induction of certain disorders by initiating inflammatory reactions in the lungs, central nervous system and lymph nodes. Various virus antigens recognized by HIV-immune CTL on the surface of the infected cell have been identified, and molecular definition of the epitopes recognized is well under way. Likewise, numerous HLA transplantation antigens that regulate HIV antigen recognition by CTL have been identified. These data are discussed with regard to the eventual development of a vaccine and of functional immunotherapies.
受感染人类对HIV的免疫反应会导致产生高频循环的HIV特异性细胞毒性T淋巴细胞（CTL）。多个实验室对这些CTL的存在及其最终的保护活性进行了研究，并将其与HIV感染的某些免疫病理表现进行了关联。HIV免疫CTL似乎通过在肺部、中枢神经系统和淋巴结引发炎症反应来参与某些疾病的诱发。已鉴定出HIV免疫CTL在受感染细胞表面识别的多种病毒抗原，对所识别表位的分子定义也正在深入研究。同样，已鉴定出许多调节CTL对HIV抗原识别的HLA移植抗原。将围绕疫苗和功能性免疫疗法的最终研发对这些数据进行讨论。
