Berns S A, Shmidt E A, Makeeva O A, Golikova A A, Ivanova T B, Nagirnyak O A, Barbarash O L
Klin Med (Mosk). 2015;93(11):28-34.
To study the relationship between polymorphous G-1082A (rs3024491) and C-592A (rs1800872) variants of the IL10 gene and multifocal atherosclerosis (MFA) in patients with acute coronary syndrome (ACS) without segment ST elevation.
Genotypes of polymorphous G-1082A (rs3024491) and C-592A (rs1800872) variants of the IL10 gene were determined in 178 patients. Interleukin-10 (IL-10) level was measured in 93 of them using solid-phase immunoenzymatic assay. All patients underwent visualization of coronary and peripheral arteries.
C-592A (rs1800872) polymorphism ofthe IL10 gene tended to be associated with type 2 diabetes mellitus in the carriers of the CC (gg) genotype and with elevated concentration of high density lipoproteins and reduced intima-media thickness in the carriers of the AA (tt) genotype. The frequency of MFA in the carriers of different genotypes of rs1800872 polymorphism was practically identical while the CA(gt) genotype was associated with more severe manifestations of atherosclerosis and AA(tt) genotype with lower frequency of peripheral artery stenosis. Patients with AA(tt) genotype of rs1800872 polymorphism had higher IL-10 levels. No relationship between rs3024491 polymorphism of IL10 gene, blood IL-10 level, clinical risk factors, and MFA was documented.
CC (gg) genotype of C-592A (rs1800872) polymorphism of the IL10 gene in patients with acute coronary syndrome (ACS) without segment ST elevation was associated with type 2 diabetes mellitus while the AA(tt) genotype of the same polymorphism with elevated concentration of high density lipoproteins, reduced intima-media thickness, low frequency of peripheral artery stenosis, and increased IL-10 production. CA (gt) genotype of rs1800872 polymorphism of the IL10 gene was associated with MFA.
研究白细胞介素10（IL10）基因多态性G-1082A（rs3024491）和C-592A（rs1800872）与无ST段抬高的急性冠状动脉综合征（ACS）患者多灶性动脉粥样硬化（MFA）之间的关系。
测定了178例患者IL10基因多态性G-1082A（rs3024491）和C-592A（rs1800872）的基因型。其中93例患者采用固相免疫酶法检测白细胞介素-10（IL-10）水平。所有患者均接受了冠状动脉和外周动脉的影像学检查。
IL10基因的C-592A（rs1800872）多态性在CC（gg）基因型携带者中倾向于与2型糖尿病相关，在AA（tt）基因型携带者中与高密度脂蛋白浓度升高和内膜中层厚度降低相关。rs1800872多态性不同基因型携带者中MFA的频率几乎相同，而CA（gt）基因型与动脉粥样硬化的更严重表现相关，AA（tt）基因型与外周动脉狭窄频率较低相关。rs1800872多态性AA（tt）基因型患者的IL-10水平较高。未发现IL10基因的rs3024491多态性、血液IL-10水平、临床危险因素和MFA之间存在关联。
无ST段抬高的急性冠状动脉综合征（ACS）患者中，IL10基因C-592A（rs1800八72）多态性的CC（gg）基因型与2型糖尿病相关，而同一多态性的AA（tt）基因型与高密度脂蛋白浓度升高、内膜中层厚度降低、外周动脉狭窄频率低和IL-10产生增加相关。IL10基因rs1800872多态性的CA（gt）基因型与MFA相关。
