Blagodatskikh K A, Evdokimova M A, Agapkina Iu V, Nikitin A G, Brovkin A N, Pushkov A A, Blagodatskikh E G, Kudriasheva O Iu, Osmolovskaia V S, Minushkina L O, Kochkina M S, Selezneva N D, Dankovtseva E N, Chumakova O S, Baklanova T N, Talyzin P A, Reznichenko N E, Donetskaia O P, Tereshchenko S N, Krasil'nikova E S, Dzhaiani N A, Akatova E V, Glezer M G, Galiavich A S, Zakirova V B, Kaziolova N A, Timofeeva I V, Iagoda A V, Boeva O I, Katel'nitskaia L I, Khorolets E V, Shlyk S V, Volkova É G, Margarian M P, Guz' O I, Konstantinov V O, Timofeeva N V, Sidorenko B A, Zateĭshchikov D A, Nosikov V V
Mol Biol (Mosk). 2010 Sep-Oct;44(5):839-46.
We investigated the association of gene IL6 G(-174)C polymorphism and gene IL10 G(-1082)A polymorphism with coronary artery disease (CAD) in the Russian population. A total of 1145 patients with CAD diagnose on the basis of clinical studies in cardiological hospitals of Moscow, St -Petersburg, Kazan, Chelyabinsk, Perm, Stavropol and Rostov-on-Don. Supervision term was 9.10 +/- 5.03 months (the maximum term 18 months). In case of gene IL10 G(-1082)A polymorphism we determined that patients with CAD diagnose and A alleles gene IL10 had unfavorable outcome more often than patients with homozygous G alleles. Survival time from end point from carrier genotype GA and AA is 11.68 +/- 0.67 months against 12.69 +/- 0.65 months from carrier phenotype GG gene IL10 (chi2 = 4.13, p = 0.042). The group studied do not differ significantly with respect to the distributions of gene IL6 G(-174)C alleles and genotypes. However in case combined group studies of gene IL10 G(-1082)A polymorphism and IL6 G(-174)C polymorphism we determined that patients with CAD diagnose and carrier genotype GG gene IL6 and genotype GA and AA gene IL10 had unfavorable outcome more often (survival time 11.01 +/- 1.24 months) than patients with genotype CC and CG gene IL6 and genotype GG gene IL10 (survival time 13.28 +/- 0.83 months) chi2 = 10.23, p = 0.017. The obtained data allows assuming the important role of the IL6 and IL10 genes which are responsible for functioning of inflammation system, in the accelerated formation of failures at the patients who had a coronary syndrome.
我们研究了俄罗斯人群中白细胞介素6（IL6）基因G(-174)C多态性和白细胞介素10（IL10）基因G(-1082)A多态性与冠状动脉疾病（CAD）的关联。共有1145例CAD患者，这些患者是在莫斯科、圣彼得堡、喀山、车里雅宾斯克、彼尔姆、斯塔夫罗波尔和顿河畔罗斯托夫等地的心脏病医院通过临床研究确诊的。观察期为9.10±5.03个月（最长18个月）。对于IL10基因G(-1082)A多态性，我们发现CAD确诊患者中携带IL10基因A等位基因的患者比携带纯合G等位基因的患者更常出现不良结局。携带基因型GA和AA的患者从终点开始的生存时间为11.68±0.67个月，而携带IL10基因GG基因型的患者为12.69±0.65个月（χ²=4.13，p=0.042）。所研究的组在IL6基因G(-174)C等位基因和基因型的分布方面没有显著差异。然而，在对IL10基因G(-1082)A多态性和IL6基因G(-174)C多态性进行联合分组研究时，我们发现CAD确诊患者中携带IL6基因GG基因型以及IL10基因GA和AA基因型的患者比携带IL6基因CC和CG基因型以及IL10基因GG基因型的患者更常出现不良结局（生存时间11.01±1.24个月）（χ²=10.23，p=0.017）。所获得的数据表明，负责炎症系统功能的IL6和IL10基因在患有冠状动脉综合征的患者加速出现功能障碍的过程中起着重要作用。
