Camilleri M
Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, Rochester, MN, USA.
Neurogastroenterol Motil. 2016 Aug;28(8):1268-71. doi: 10.1111/nmo.12823. Epub 2016 Mar 14.
Most drug-drug interactions involve overlap or competition in drug metabolic pathways. However, there are medications, typically resins, whose function is to bind injurious substances such as bile acids or potassium within the digestive tract. The objective of this article is to review the functions of the stomach and the kinetics of emptying of different food forms or formulations to make recommendations on timing of medication administration in order to avoid intragastric drug interactions. Based on the profiles and kinetics of emptying of liquid nutrients and homogenized solids, a window of 3 h between administration of a resin drug and another 'target' medication would be expected to allow a median of 80% of medications with particle size <1 mm to empty from the stomach and, hence, avoid potential interaction such as binding of the 'target' medication within the stomach.
大多数药物相互作用涉及药物代谢途径的重叠或竞争。然而，有一些药物，通常是树脂类药物，其功能是在消化道内结合有害物质，如胆汁酸或钾。本文的目的是回顾胃的功能以及不同食物形式或制剂的排空动力学，以便就药物给药时间提出建议，以避免胃内药物相互作用。根据液体营养物和均质化固体的排空曲线和动力学，预计在树脂类药物与另一种“目标”药物给药之间留出3小时的时间窗口，可使粒径<1毫米的药物中位数有80%从胃中排空，从而避免潜在的相互作用，如“目标”药物在胃内被结合。
