p73与FoxJ1：多纤毛上皮细胞的编程
p73 and FoxJ1: Programming Multiciliated Epithelia.
作者信息
Jackson Peter K, Attardi Laura D
机构信息
Stanford University School of Medicine, Baxter Laboratory, Departments of Microbiology and Immunology and Pathology, Stanford, CA 94305, USA.
Stanford University School of Medicine, Department of Radiation Oncology and Department of Genetics, Stanford, CA 94305, USA.
出版信息
Trends Cell Biol. 2016 Apr;26(4):239-240. doi: 10.1016/j.tcb.2016.03.001. Epub 2016 Mar 14.
Abstract
The mysteriously diverse phenotypes in mice lacking the p53 homolog p73 are recently unified by new analysis showing p73 is required for formation of multiciliated epithelia. p73 directly activates FoxJ1, the central transcriptional driver for multiciliation, and induces a host of genes critical for ciliogenesis.
摘要
最近，通过新的分析揭示了缺乏p53同源物p73的小鼠中神秘多样的表型，这些表型得到了统一，该分析表明p73是多纤毛上皮形成所必需的。p73直接激活FoxJ1，后者是多纤毛形成的核心转录驱动因子，并诱导一系列对纤毛发生至关重要的基因。
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本文引用的文献
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p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network.多纤毛形成需要p73并调节与Foxj1相关的基因网络。
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