Materna-Kiryluk Anna, Więckowska Barbara, Wiśniewska Katarzyna, Czyżewska Małgorzata, Godula-Stuglik Urszula, Baumert Małgorzata, Margol Ryszard, Latos-Bieleńska Anna
Poznan University of Medical Sciences, Poznań, Poland (Department of Medical Genetics).
Poznan University of Medical Sciences, Poznań, Poland (Department of Computer Science and Statistics).
Int J Occup Med Environ Health. 2016;29(3):461-70. doi: 10.13075/ijomeh.1896.00624.
The aims of this study were: to evaluate the prevalence of abdominal wall defects in the Polish population, to analyze temporal trends in the prevalence, to identify areas (clusters) of high risk of abdominal wall defects, and to characterize, with respect to epidemiology, children with abdominal wall defects and their mothers in the area defined as a cluster.
We used isolated congenital malformations (gastroschisis Q79.3 and omphalocele Q79.2 according to the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10, the extended version)) data reported to the Polish Registry of Congenital Malformations (PRCM) over the years 1998- 2008 based on the population of 2 362 502 live births. We analyzed 11 administrative regions of Poland with complete epidemiologic data.
Of 11 regions, 2 had a significantly higher standardized prevalence of isolated gastroschisis: Dolnośląskie (1.7/10 000 live births, p = 0.0052) and Śląskie (1.9/10 000 live births, p < 0.0001). Furthermore, within the region of Dolnośląskie, we defined a clear prevalence of the isolated gastroschisis cluster (p = 0.023). We comprehensively examined demographic and socio-economic risk factors for abdominal wall defects in this area, and we found that these factors failed to account for the cluster.
We identified a distinct prevalence cluster for isolated gastroschisis, although a precise reason for the disease clustering in this region remains unknown. Cluster identification enables more focused research aimed at identification of specific factors with teratogenic effects.
本研究的目的是：评估波兰人群中腹壁缺陷的患病率，分析患病率的时间趋势，确定腹壁缺陷的高风险区域（聚集区），并从流行病学角度描述在定义为聚集区的区域内患有腹壁缺陷的儿童及其母亲的特征。
我们使用了1998 - 2008年期间向波兰先天性畸形登记处（PRCM）报告的孤立性先天性畸形（根据《疾病和相关健康问题国际统计分类》第10版（ICD - 10，扩展版），腹裂Q79.3和脐膨出Q79.2）数据，基于2362502例活产的人口。我们分析了波兰11个行政区的完整流行病学数据。
在11个区域中，有2个区域的孤立性腹裂标准化患病率显著更高：下西里西亚省（1.7/10000例活产，p = 0.0052）和西里西亚省（1.9/10000例活产，p < 0.0001）。此外，在下西里西亚省内，我们明确界定了孤立性腹裂聚集区的患病率（p = 0.023）。我们全面检查了该地区腹壁缺陷的人口统计学和社会经济风险因素，发现这些因素无法解释该聚集区的情况。
我们确定了孤立性腹裂的一个明显的患病率聚集区，尽管该疾病在该地区聚集的确切原因仍然未知。聚集区的识别有助于开展更有针对性的研究，旨在识别具有致畸作用的特定因素。
