Dickey R P, Matis R, Olar T T, Curole D N, Taylor S N, Rye P H
Fertility Institute of New Orleans, Louisiana 70128.
J In Vitro Fert Embryo Transf. 1989 Oct;6(5):294-7. doi: 10.1007/BF01139185.
An eleven-year review of treatment records of patients who became pregnant as a result of infertility treatment (n = 3692) was conducted. All records were examined to determine whether clomiphene citrate (CC) was used in the cycle of conception and whether or not an ectopic pregnancy occurred. Data were additionally analyzed for the incidence of ectopic pregnancy with and without assisted reproductive technology (ART). The incidence of ectopic pregnancy was similar between CC (3.4%) and non-CC (3.4%) treatment groups receiving non-ART treatment. For non-ART treatments, tubal disease and severe endometriosis resulted in an increase in ectopic pregnancies independent of CC use. The incidence of ectopic pregnancy in patients receiving CC + human menopausal gonadotropin (hMG) for in vitro fertilization (5.4%) and gamete intrafallopian transfer (3.1%) was similar compared to ART treatments with hMG alone. The incidence of ectopic pregnancy was more closely associated with infertility diagnosis rather than CC use.
对因不孕治疗而怀孕的患者（n = 3692）的治疗记录进行了为期11年的回顾。检查所有记录以确定在受孕周期中是否使用了枸橼酸氯米芬（CC）以及是否发生了异位妊娠。还分析了有无辅助生殖技术（ART）情况下异位妊娠的发生率。接受非ART治疗的CC治疗组（3.4%）和非CC治疗组（3.4%）的异位妊娠发生率相似。对于非ART治疗，输卵管疾病和严重子宫内膜异位症导致异位妊娠增加，与是否使用CC无关。接受CC + 人绝经期促性腺激素（hMG）进行体外受精（5.4%）和配子输卵管内移植（3.1%）的患者中异位妊娠的发生率与单独使用hMG的ART治疗相似。异位妊娠的发生率与不孕诊断的关联更为密切，而非与CC的使用有关。
