Cohen J, Mayaux M J, Guihard-Moscato M L, Schwartz D
Hum Reprod. 1986 Jun;1(4):255-8. doi: 10.1093/oxfordjournals.humrep.a136396.
In a multi-centric study undertaken on 1163 pregnancies obtained by in-vitro fertilization, a 5% risk of ectopic pregnancies was observed. This figure is certainly higher than that admitted for natural reproduction. After simultaneous adjusting for all variables in our data by means of a multiple logistic regression technique, two factors have specific influence: the therapeutic use of clomiphene citrate which increased the rate of ectopic pregnancies from 3 to 6% and the number of patent Fallopian tubes with a change in ectopic pregnancies rate from 3 or 4% (with 0 or 2 patent tubes) to 13% (with one patent tube). These results suggest various physiologic hypotheses as well as therapeutic considerations.
在一项针对1163例体外受精妊娠进行的多中心研究中，观察到异位妊娠风险为5%。这个数字肯定高于自然生殖公认的风险。通过多元逻辑回归技术对我们数据中的所有变量进行同时调整后，有两个因素具有特定影响：枸橼酸氯米芬的治疗性使用使异位妊娠率从3%提高到6%，以及输卵管通畅情况，异位妊娠率从3%或4%（0条或2条输卵管通畅）变为13%（1条输卵管通畅）。这些结果提示了各种生理假设以及治疗方面的考虑。
