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克罗米芬治疗后双侧输卵管异位妊娠:一例报告

Bilateral Tubal Ectopic Pregnancy Following Clomiphene Administration: A Case Report.

作者信息

Benz Alicia M, Price Caitlin C, Ocon Fernando J

机构信息

Obstetrics and Gynecology, Lincoln Memorial University DeBusk College of Osteopathic Medicine, Houston, USA.

Obstetrics and Gynecology, HCA Houston Healthcare Southeast, Pasadena, USA.

出版信息

Cureus. 2022 Sep 9;14(9):e28977. doi: 10.7759/cureus.28977. eCollection 2022 Sep.

DOI:10.7759/cureus.28977
PMID:36159361
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9495284/
Abstract

A bilateral tubal ectopic pregnancy is the rarest form of extrauterine pregnancy and is extremely difficult to diagnose due to an initial presentation that is nearly indistinguishable from unilateral tubal ectopic pregnancy. We report a case of a 27-year-old primigravida woman who presented to our clinic with mild cramping and vaginal bleeding following the administration of clomiphene. Ultrasound confirmed the presence of a left-sided ectopic pregnancy. The patient underwent laparoscopy and was found to have a mass in the contralateral fallopian tube. Histologic evaluation of the specimens from both fallopian tubes confirmed the presence of a simultaneous bilateral tubal ectopic pregnancy. While no current guidelines exist for the management of bilateral ectopic pregnancies, we stress the importance of direct visualization of both fallopian tubes during laparoscopy for any suspected ectopic pregnancy.

摘要

双侧输卵管异位妊娠是宫外孕最罕见的形式,由于其最初的表现与单侧输卵管异位妊娠几乎无法区分,因此极难诊断。我们报告一例27岁初孕妇,在服用克罗米芬后出现轻度腹痛和阴道出血,前来我院就诊。超声检查证实左侧宫外孕。患者接受了腹腔镜检查,发现对侧输卵管有肿物。对双侧输卵管标本进行组织学评估,证实同时存在双侧输卵管异位妊娠。虽然目前尚无关于双侧异位妊娠管理的指南,但我们强调,对于任何疑似异位妊娠,在腹腔镜检查期间直接观察双侧输卵管的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2b/9495284/864dd5199ec8/cureus-0014-00000028977-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2b/9495284/2f8ebd32734d/cureus-0014-00000028977-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2b/9495284/0d7129c68940/cureus-0014-00000028977-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2b/9495284/012b097eb3de/cureus-0014-00000028977-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2b/9495284/88482ddde0ef/cureus-0014-00000028977-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2b/9495284/864dd5199ec8/cureus-0014-00000028977-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2b/9495284/2f8ebd32734d/cureus-0014-00000028977-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2b/9495284/0d7129c68940/cureus-0014-00000028977-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2b/9495284/012b097eb3de/cureus-0014-00000028977-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2b/9495284/88482ddde0ef/cureus-0014-00000028977-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2b/9495284/864dd5199ec8/cureus-0014-00000028977-i05.jpg

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本文引用的文献

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Case Rep Obstet Gynecol. 2021 Jun 19;2021:5588869. doi: 10.1155/2021/5588869. eCollection 2021.
2
Relation of Chlamydia trachomatis infections to ectopic pregnancy: A meta-analysis and systematic review.沙眼衣原体感染与异位妊娠的关系:一项荟萃分析及系统评价
Medicine (Baltimore). 2020 Jan;99(1):e18489. doi: 10.1097/MD.0000000000018489.
3
Comparison of the Fertility Outcome of Salpingotomy and Salpingectomy in Women with Tubal Pregnancy: A Systematic Review and Meta-Analysis.
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PLoS One. 2016 Mar 25;11(3):e0152343. doi: 10.1371/journal.pone.0152343. eCollection 2016.
4
Misdiagnosis of bilateral tubal pregnancy: a case report.双侧输卵管妊娠误诊:一例报告
J Med Case Rep. 2014 Oct 14;8:342. doi: 10.1186/1752-1947-8-342.
5
Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy.沙眼衣原体感染通过 TLR2 和 NFκB 激活增加输卵管 PROKR2,导致易发生异位妊娠的微环境。
Am J Pathol. 2011 Jan;178(1):253-60. doi: 10.1016/j.ajpath.2010.11.019. Epub 2010 Dec 23.
6
Clomiphene citrate causes aberrant tubal apoptosis and estrogen receptor activation in rat fallopian tube: implications for tubal ectopic pregnancy.枸橼酸氯米芬导致大鼠输卵管异常凋亡和雌激素受体激活:对输卵管异位妊娠的影响。
Biol Reprod. 2009 Jun;80(6):1262-71. doi: 10.1095/biolreprod.108.074237. Epub 2009 Feb 11.
7
Bilateral tubal gestation.双侧输卵管妊娠
Br Med J. 1948 Apr 17;1(4554):734. doi: 10.1136/bmj.1.4554.734.
8
Bilateral tubal pregnancy. A report of an unusual case.双侧输卵管妊娠。一例罕见病例报告。
J Reprod Med. 1998 Aug;43(8):707-9.
9
Bilateral tubal pregnancy with vaginal delivery.
Obstet Gynecol. 1982 Nov;60(5):664-6.
10
The occurrence of ectopic pregnancy with and without clomiphene citrate use in assisted and nonassisted reproductive technology.在辅助生殖技术和非辅助生殖技术中,使用与未使用枸橼酸氯米芬时异位妊娠的发生情况。
J In Vitro Fert Embryo Transf. 1989 Oct;6(5):294-7. doi: 10.1007/BF01139185.