Spagnoli L G, Mauriello A, Bonanno E, Santeusanio G, Fieschi C, Fiorani P, Zanette E
Dipartimento di Chirurgia, II Università di Roma, Tor Vergata.
Int Angiol. 1989 Oct-Dec;8(4):216-23.
The ultrasound image of the fibroatheromatous plaque has to date been unable to reveal the presence or absence of complications as shown by histology, such as thrombosis and intraplaque hemorrhage. We propose a novel densitometric method for determining the composition of the plaque at the echotomography, along with a new classification based on mathematical models drawn from the optical density distribution curve. This approach avails of an extremely high sensitivity. Percent areas occupied by thrombosis, intraplaque hemorrhage and atheroma in histologic sections have been shown to correspond to hyporeflecting areas in echotomographic images, whereas those occupied by calcium and fibrous tissue correspond to reflecting areas with or without acoustic shadow, respectively. This method may prove to have an important role in the non-invasive monitoring of even slight changes during progression or regression of the fibroatheromatous plaque.
迄今为止，纤维粥样斑块的超声图像无法显示组织学所显示的并发症的存在与否，如血栓形成和斑块内出血。我们提出了一种新的密度测定方法，用于在超声断层扫描中确定斑块的成分，并基于从光密度分布曲线得出的数学模型进行新的分类。这种方法具有极高的灵敏度。组织学切片中血栓形成、斑块内出血和动脉粥样硬化所占的百分比面积已被证明分别对应于超声断层图像中的低回声区域，而钙和纤维组织所占的区域分别对应于有或没有声影的回声区域。这种方法可能在纤维粥样斑块进展或消退过程中对即使是微小变化的无创监测中发挥重要作用。
