Zeng Yun, Ma Jingwen, Zhang Shaojuan, Wu Daocheng
Key Laboratory of Biomedical Information Engineering, Ministry of Education, School of Life Science and Technology, Xi`an Jiaotong University; Xi`an, P. R. China.
Curr Med Chem. 2016;23(17):1775-800. doi: 10.2174/0929867323666160321122023.
Tissue hypoxia may occur in many diseases, specifically during the occurrence and growth of malignant solid-tumors. Targeting hypoxia is one of the most significant characteristics of tumors in diagnosis, monitoring, and treatment. This review summarizes the current oxygen-sensitive imaging agents used to target tumor hypoxia, including positron-emission computed tomography/single photon-emission computed tomography radionuclide labeled tracers, magnetic resonance imaging contrast agents for hypoxia detection, and hypoxia-sensitive optical imaging probes. Researchers have utilized nanotechnology as a useful toolkit to improve the effects of oxygen-sensitive imaging agents. We emphasize the progress and influence of nanotechnology in these materials and technologies. This review demonstrates that hypoxia imaging agents have promising prospects, and may provide helpful information for tumor diagnosis and prognosis.
组织缺氧可能发生在许多疾病中，尤其是在恶性实体瘤的发生和生长过程中。靶向缺氧是肿瘤在诊断、监测和治疗方面最重要的特征之一。本综述总结了目前用于靶向肿瘤缺氧的氧敏感成像剂，包括正电子发射计算机断层扫描/单光子发射计算机断层扫描放射性核素标记示踪剂、用于缺氧检测的磁共振成像造影剂以及缺氧敏感光学成像探针。研究人员已将纳米技术作为一种有用的工具来提高氧敏感成像剂的效果。我们强调了纳米技术在这些材料和技术中的进展及影响。本综述表明，缺氧成像剂具有广阔的前景，可能为肿瘤诊断和预后提供有用信息。
