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Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes.
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GLIS3: A Critical Transcription Factor in Islet β-Cell Generation.
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Substance P preserves pancreatic β-cells in type 1 and type 2 diabetic mice.
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DNA damage to β cells in culture recapitulates features of senescent β cells that accumulate in type 1 diabetes.
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The IGFBP3/TMEM219 pathway regulates beta cell homeostasis.
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Investigation of type 1 diabetes in NOD mice knockout for the osteopontin gene.
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Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation.
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2
Mapping disease loci to biological processes via joint pleiotropic and epigenomic partitioning.
medRxiv. 2025 May 6:2025.05.05.25327017. doi: 10.1101/2025.05.05.25327017.
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DNA repair protein RAD50 is involved in the streptozotocin-induced diabetes susceptibility of mice.
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Genetics of type-1 diabetes.
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Circulating pancreatic enzyme levels are a causal biomarker of type 1 diabetes.
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Untangling the genetics of beta cell dysfunction and death in type 1 diabetes.
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2
Emerging functions of the unfolded protein response in immunity.
Nat Immunol. 2014 Oct;15(10):910-9. doi: 10.1038/ni.2991.
3
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13924-9. doi: 10.1073/pnas.1402665111. Epub 2014 Sep 8.
5
MANF is indispensable for the proliferation and survival of pancreatic β cells.
Cell Rep. 2014 Apr 24;7(2):366-375. doi: 10.1016/j.celrep.2014.03.023. Epub 2014 Apr 13.
7
Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD.
Mol Biol Cell. 2014 Apr;25(7):1050-60. doi: 10.1091/mbc.E13-06-0350. Epub 2014 Jan 29.
8
Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes.
Sci Transl Med. 2013 Nov 13;5(211):211ra156. doi: 10.1126/scitranslmed.3006534.
9
A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining.
Oncogene. 2014 May 22;33(21):2748-57. doi: 10.1038/onc.2013.234. Epub 2013 Jun 10.

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