Ban Chun-Xia, Zhong Li, Wang Tao, Zhu Min-Jie, Wang Jing-Hua, Zhang Zhen-Lian, Wang Zhe, Su Ning, Liu Yuan-Yuan, Shi Yan-Chen, Xiao Shi-Fu, Li Xia
Department of Psychogeriatrics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, China.
PLoS One. 2016 Mar 21;11(3):e0151336. doi: 10.1371/journal.pone.0151336. eCollection 2016.
Despite Apolipoprotein E (ApoE) being one of the main apolipoproteins in the blood, the association between its genotype and the high cholesterol or blood glucose levels commonly seen in clinical practice is inconclusive. Such research is also lacking in the Han population. The aim of this study was to investigate the association between APOE genotype, diabetes, and plasma glucose and lipid levels. We included 243 community-dwelling elderly residents in this study. Participant APOE genotypes were assessed and were simultaneously tested for weight, height, blood glucose, triglycerides, cholesterol, and high- and low-density lipoprotein. In addition, gender, age, years of education, cognitive function, and medical history was recorded. Subjects were divided into 3 groups based on APOE genotype: APOE ε2 group (ε2/ε2 and ε2/ε3), APOE ε3 group (ε3/ε3), and APOE ε4 group (ε2/ε4, ε3/ε4 and ε4/ε4). Comparisons between groups were conducted for the incidence of diabetes, high blood pressure, and dementia, as well as for differences in body-mass index, fasting plasma glucose, and blood lipids. The APOE ε3/ε3 genotype exhibited the highest frequency (70.4%) among the subjects. Participants in the APOE ε3 group demonstrated significantly higher levels of fasting plasma glucose than those in the APOE ε2 and APOE ε4 groups (P<0.05). The APOE ε3 group had slightly higher abnormal fasting plasma glucose values than did the APOE ε2 group (P = 0.065). Furthermore, the APOE3 genotype was significantly correlated with both fasting plasma glucose level and glucose abnormality (P< 0.05) and trended toward statistically significant correlation with diabetes (P = 0.082). The correlation between APOE2 and low low-density lipoprotein levels also approached statistical significance (P = 0.052). Thus, elderly community dwelling residents of Han ethnicity carrying the APOE ε3/ε3 genotype might have higher plasma glucose levels and a higher occurrence of diabetes.
尽管载脂蛋白E（ApoE）是血液中主要的载脂蛋白之一，但其基因型与临床实践中常见的高胆固醇或血糖水平之间的关联尚无定论。汉族人群中也缺乏此类研究。本研究的目的是调查APOE基因型、糖尿病与血浆葡萄糖和脂质水平之间的关联。本研究纳入了243名社区居住的老年居民。对参与者的APOE基因型进行评估，并同时检测体重、身高、血糖、甘油三酯、胆固醇以及高密度和低密度脂蛋白。此外，记录性别、年龄、受教育年限、认知功能和病史。根据APOE基因型将受试者分为3组：APOE ε2组（ε2/ε2和ε2/ε3）、APOE ε3组（ε3/ε3）和APOE ε4组（ε2/ε4、ε3/ε4和ε4/ε4）。对各组之间的糖尿病、高血压和痴呆发病率以及体重指数、空腹血糖和血脂差异进行比较。APOE ε3/ε3基因型在受试者中出现频率最高（70.4%）。APOE ε3组参与者的空腹血糖水平显著高于APOE ε2组和APOE ε4组（P<0.05）。APOE ε3组的空腹血糖异常值略高于APOE ε2组（P = 0.065）。此外，APOE3基因型与空腹血糖水平和血糖异常均显著相关（P<0.05），与糖尿病的相关性有统计学意义的趋势（P = 0.082）。APOE2与低密度脂蛋白水平低之间的相关性也接近统计学意义（P = 0.052）。因此，携带APOE ε3/ε3基因型的汉族社区老年居民可能有更高的血浆葡萄糖水平和更高的糖尿病发生率。
