用于细胞内隔室化学反应性空间分析的反应性低聚（对苯撑乙烯）材料的制备。
Preparation of Reactive Oligo(p-Phenylene Vinylene) Materials for Spatial Profiling of the Chemical Reactivity of Intracellular Compartments.
机构信息
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, P. R. China.
出版信息
Adv Mater. 2016 May;28(19):3749-54. doi: 10.1002/adma.201600106. Epub 2016 Mar 22.
An oligo(p-phenylene vinylene) derivative (OPV-pfp) functionalized with pentafluorophenol active ester is designed and synthesized. The high reactivity of OPV-pfp with biological small molecules or macromolecules containing amino groups under physiological conditions leads to spectral changes of OPV-pfp; thus, spatial reactivity discrimination for different subcellular structures inside cells is realized by triggering and imaging the fluorescence signal change of the OPV-pfp.
设计并合成了一种功能化的聚对苯乙炔衍生物（OPV-pfp），其带有五氟苯酚活性酯。OPV-pfp 与含有氨基的生物小分子或生物大分子在生理条件下具有很高的反应活性，导致 OPV-pfp 的光谱发生变化；因此，通过触发和成像 OPV-pfp 的荧光信号变化，实现了对细胞内不同亚细胞结构的空间反应性区分。
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