由Wnt1启动子驱动的Cre重组酶导致14-3-3ε和14-3-3ζ缺乏会引起色素沉着缺陷。
Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects.
作者信息
Cornell Brett, Toyo-oka Kazuhito
机构信息
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, 19129, USA.
出版信息
BMC Res Notes. 2016 Mar 22;9:180. doi: 10.1186/s13104-016-1980-z.
BACKGROUND
The seven 14-3-3 protein isoforms bind to numerous proteins and are involved in a wide variety of cellular events, including the cell cycle, cell division, apoptosis and cancer. We previously found the importance of 14-3-3 proteins in neuronal migration of pyramidal neurons in the developing cortex. Here, we test the function of 14-3-3 proteins in the development of neural crest cells in vivo using mouse genetic approaches.
RESULTS
We found that 14-3-3 proteins are important for the development of neural crest cells, in particular for the pigmentation of the fur on the ventral region of mice.
CONCLUSIONS
Our data obtained from the 14-3-3ε/14-3-3ζ/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages.
背景
七种14-3-3蛋白异构体可与多种蛋白质结合，并参与包括细胞周期、细胞分裂、细胞凋亡和癌症在内的各种细胞活动。我们之前发现14-3-3蛋白在发育中的皮质锥体细胞的神经元迁移中具有重要作用。在此，我们使用小鼠遗传学方法在体内测试14-3-3蛋白在神经嵴细胞发育中的功能。
结果
我们发现14-3-3蛋白对神经嵴细胞的发育很重要，特别是对小鼠腹部区域毛发的色素沉着。
结论
我们从14-3-3ε/14-3-3ζ/Wnt1-Cre小鼠获得的数据有力地表明了14-3-3蛋白在黑素细胞谱系发育中的重要性。
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