Bates Philip D
Department of Chemistry and Biochemistry, The University of Southern Mississippi, 118 College Dr. #5043, Hattiesburg, MS 39406-0001, United States.
Biochim Biophys Acta. 2016 Sep;1861(9 Pt B):1214-1225. doi: 10.1016/j.bbalip.2016.03.021. Epub 2016 Mar 19.
Plant oil biosynthesis involves a complex metabolic network with multiple subcellular compartments, parallel pathways, cycles, and pathways that have a dual function to produce essential membrane lipids and triacylglycerol. Modern molecular biology techniques provide tools to alter plant oil compositions through bioengineering, however with few exceptions the final composition of triacylglycerol cannot be predicted. One reason for limited success in oilseed bioengineering is the inadequate understanding of how to control the flux of fatty acids through various fatty acid modification, and triacylglycerol assembly pathways of the lipid metabolic network. This review focuses on the mechanisms of acyl flux through the lipid metabolic network, and highlights where uncertainty resides in our understanding of seed oil biosynthesis. This article is part of a Special Issue entitled: Plant Lipid Biology edited by Kent D. Chapman and Ivo Feussner.
植物油生物合成涉及一个复杂的代谢网络，该网络具有多个亚细胞区室、平行途径、循环以及具有双重功能的途径，以产生必需的膜脂和三酰甘油。现代分子生物学技术提供了通过生物工程改变植物油成分的工具，然而，除了少数例外，三酰甘油的最终成分无法预测。油料作物生物工程取得有限成功的一个原因是对如何通过各种脂肪酸修饰以及脂质代谢网络的三酰甘油组装途径来控制脂肪酸通量的理解不足。本综述着重于通过脂质代谢网络的酰基通量机制，并突出了我们对种子油生物合成的理解中存在不确定性的地方。本文是由肯特·D·查普曼和伊沃·费斯纳编辑的名为《植物脂质生物学》的特刊的一部分。
