Yim Hyun-Jeong, Song Ji Eun, Kim Ji-Eun, Son Ga Hyun, Lee Keun Young
Department of Obstetrics and Gynecology, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea.
Obstet Gynecol Sci. 2016 Mar;59(2):97-102. doi: 10.5468/ogs.2016.59.2.97. Epub 2016 Mar 16.
To assess the role of preoperative and postoperative serum C-reactive protein (CRP) level on the prediction of pregnancy outcomes following ultrasound-indicated cerclage (UIC).
We retrospectively reviewed the medical records 44 women who underwent UIC between January 2011 and December 2011. UIC was performed between 14 and 24 weeks of gestation in women with short cervix. We divided UIC patients into two groups according to the gestational age at delivery (34 weeks) and compared the two groups. Group A was defined as patients who delivered ≥34 weeks of gestation, and group B as patients delivered <34 weeks. Correlation and receiver-operating characteristic curves were also analyzed for the prediction of preterm birth after UIC.
Thirty women delivered ≥34 weeks (group A) and 14 women delivered <34 weeks (group B). Pre- and post-cerclage CRP were significantly lower in group A (pre-cerclage CRP, 1.1±1.0 vs. 11.4±6.2 mg/dL, P<0.001; post-cerclage CRP, 0.6±0.5 vs. 7.4±7.2 mg/dL, P<0.001). The mean gestational age at delivery in group A was 37.7±1.8 weeks and that in group B was 26.9±4.3 weeks (P<0.001). There were significant negative correlations between pre- and post-cerclage CRP and latency from UIC to delivery (r=-0.82, P<0.001; r=-0.70, P<0.001, respectively).
Both pre- and post-cerclage CRP were useful in predicting the preterm birth following UIC.
评估术前及术后血清C反应蛋白（CRP）水平在超声引导下宫颈环扎术（UIC）后妊娠结局预测中的作用。
我们回顾性分析了2011年1月至2011年12月期间接受UIC的44例女性的病历。UIC在宫颈短的女性妊娠14至24周期间进行。我们根据分娩时的孕周（34周）将UIC患者分为两组并进行比较。A组定义为孕周≥34周分娩的患者，B组为孕周<34周分娩的患者。还分析了相关性及受试者工作特征曲线以预测UIC后的早产情况。
30例女性孕周≥34周分娩（A组），14例女性孕周<34周分娩（B组）。A组环扎术前及术后的CRP水平显著更低（环扎术前CRP，1.1±1.0 vs. 11.4±6.2 mg/dL，P<0.001；环扎术后CRP，0.6±0.5 vs. 7.4±7.2 mg/dL，P<0.001）。A组的平均分娩孕周为37.7±1.8周，B组为26.9±4.3周（P<0.001）。环扎术前及术后的CRP与从UIC到分娩的潜伏期之间存在显著负相关（分别为r=-0.82，P<0.001；r=-0.70，P<0.001）。
环扎术前及术后的CRP水平均有助于预测UIC后的早产情况。
