Center for Research in Environmental Epidemiology, Barcelona, Catalonia, Spain.
Am J Obstet Gynecol. 2011 Feb;204(2):164.e1-9. doi: 10.1016/j.ajog.2010.08.056. Epub 2010 Oct 25.
We assessed whether maternal C-reactive protein (CRP) levels during pregnancy and CRP gene variations are associated with wheezing and lower respiratory tract infections (LRTIs) in offspring.
Information on wheezing and LRTIs in the offspring at 6 and 14 months of age, and maternal CRP levels and genotype was obtained from a population-based birth cohort.
A total of 63 children (12.5%) experienced recurrent wheezing and 61 (12.4%) a recurrent diagnosis of LRTIs. Children in the highest tertile of maternal CRP levels had a higher risk of experiencing recurrent wheezing (adjusted odds ratio, 2.87; 95% confidence interval, 1.23-6.71) and being diagnosed with recurrent LRTIs (odds ratio, 2.37; 95% confidence interval, 1.01-5.55), as compared with children in the lowest tertile. The rs1205 polymorphism influenced maternal serum CRP levels but not the risk of the offspring outcomes.
Higher CRP levels in pregnancy are associated with wheezing and LRTIs in offspring. However, genetic variation in CRP influencing maternal levels is not related to these phenotypes.
我们评估了孕妇 C 反应蛋白（CRP）水平和 CRP 基因变异与后代喘息和下呼吸道感染（LRTIs）的相关性。
从一项基于人群的出生队列中获取了后代在 6 个月和 14 个月时喘息和 LRTIs 的信息，以及母亲的 CRP 水平和基因型。
共有 63 名儿童（12.5%）出现反复喘息，61 名儿童（12.4%）反复诊断为 LRTIs。与 CRP 水平最低的三分位组儿童相比，最高三分位组儿童出现反复喘息（调整后的优势比，2.87；95%置信区间，1.23-6.71）和反复诊断为 LRTIs（比值比，2.37；95%置信区间，1.01-5.55）的风险更高。rs1205 多态性影响母体血清 CRP 水平，但不影响后代结局的风险。
妊娠期间 CRP 水平升高与后代喘息和 LRTIs 相关。然而，影响母体水平的 CRP 基因变异与这些表型无关。
