Suppr超能文献

发情周期和妊娠期第12 - 14天猪子宫平滑肌收缩性的比较。

Comparison of the porcine uterine smooth muscle contractility on days 12-14 of the estrous cycle and pregnancy.

作者信息

Markiewicz Włodzimierz, Bogacki Marek, Blitek Michał, Jaroszewski Jerzy Jan

机构信息

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Street 13, 10-718, Olsztyn, Poland.

Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Bydgoska Street 7, 10-243, Olsztyn, Poland.

出版信息

Acta Vet Scand. 2016 Mar 22;58:20. doi: 10.1186/s13028-016-0201-z.

Abstract

BACKGROUND

Uterine contractile activity is very important for many reproductive functions including embryo transport, implantation, gestation and parturition. Abnormal contractility leads to implantation failure, spontaneous miscarriage, preterm birth and many other disorders. The objective of the present study was to assess the effects of acetylcholine (ACh), noradrenaline (NA), oxytocin (OT) and prostaglandins F2α (PGF2α) and E2 (PGE2) on the contraction of uterine strips collected from the horns of cyclic gilts (12-14 days of the estrous cycle-group I) and from pregnant (12-14 days after first insemination gilts in which one of the uterine horn was gravid (group IIa) and the second one was non-gravid (group IIb). Uterine strips consisting of the endometrium with the myometrium and myometrium alone were examined.

RESULTS

ACh increased the tension in all groups as compared to the pretreatment period, and the increase was the highest in group IIb; the amplitude decreased in all groups, and the frequency increased mainly in groups I and IIa. NA did not affect the tension in any group, but decreased the amplitude and frequency in group IIb as compared to groups I and IIa. OT caused the highest increase in the tension in group IIb, a decrease in the amplitude and an increase in the frequency of contractions as compared to the pretreatment period. PGF2α induced the highest increase in the tension and amplitude in group IIb, with a decline in the frequency in this group. PGE2 increased the tension and frequency only in group IIb, and caused the greatest eduction in the amplitude in this group.

CONCLUSIONS

These results indicate that contractility of the porcine smooth muscle collected from uterine horns with embryos was different from those obtained from the uterine horns without embryos and the horns of cyclic gilts.

摘要

背景

子宫收缩活动对许多生殖功能非常重要,包括胚胎运输、着床、妊娠和分娩。异常收缩会导致着床失败、自然流产、早产和许多其他病症。本研究的目的是评估乙酰胆碱(ACh)、去甲肾上腺素(NA)、催产素(OT)、前列腺素F2α(PGF2α)和E2(PGE2)对从发情周期母猪子宫角(发情周期第12 - 14天,I组)以及妊娠母猪(首次配种后12 - 14天,其中一个子宫角妊娠(IIa组),另一个子宫角未妊娠(IIb组))采集的子宫条收缩的影响。对包含子宫内膜和肌层的子宫条以及单独的肌层进行了检查。

结果

与预处理期相比,ACh使所有组的张力增加,其中IIb组增加幅度最大;所有组的振幅均降低,频率增加主要见于I组和IIa组。NA对任何组的张力均无影响,但与I组和IIa组相比,IIb组的振幅和频率降低。与预处理期相比,OT使IIb组的张力增加幅度最大,收缩振幅降低,频率增加。PGF2α使IIb组的张力和振幅增加幅度最大,该组频率下降。PGE2仅使IIb组的张力和频率增加,且该组振幅降低幅度最大。

结论

这些结果表明,从有胚胎的子宫角采集的猪平滑肌收缩性与从无胚胎的子宫角以及发情周期母猪子宫角采集的平滑肌收缩性不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d3/4802636/e4f138ad4787/13028_2016_201_Fig1_HTML.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验