Rao C V
Departments of Cellular Biology and Pharmacology, Molecular and Human Genetics and Obstetrics and Gynecology, Reproduction and Development Program, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA
Reprod Sci. 2016 Nov;23(11):1451-1458. doi: 10.1177/1933719116639139. Epub 2016 Mar 22.
Painful bladder syndrome/interstitial cystitis is a debilitating chronic bladder disease that primarily affects women. The disease is due to a damage of urothelial cell lining. As a result, potassium particles and other toxic substances in urine can leak into bladder mucosa, causing the symptoms of lower abdominal/pelvic discomfort, pain, increased urination frequency, urgency, nocturia, and so on, all of which can substantially reduce the quality of daily life. There are multiple symptom reliving therapies. Among them, only pentosan polysulfate sodium, sold under the brand name of Elmiron, has been approved for oral use by US Food and Drug Administration. It provides the relief after several months of use. Based on the scientific leads presented in this article, we propose that human chorionic gonadotropin has a therapeutic potential that is worth investigating for the treatment of this disease.
疼痛性膀胱综合征/间质性膀胱炎是一种使人衰弱的慢性膀胱疾病，主要影响女性。该疾病是由于膀胱上皮细胞内衬受损所致。因此，尿液中的钾颗粒和其他有毒物质会渗入膀胱黏膜，导致下腹/盆腔不适、疼痛、尿频、尿急、夜尿等症状，所有这些都会严重降低日常生活质量。有多种缓解症状的疗法。其中，只有以Elmiron为品牌名销售的聚磺基水杨酸铋已被美国食品药品监督管理局批准口服使用。使用几个月后症状会有所缓解。基于本文提出的科学线索，我们认为人绒毛膜促性腺激素具有治疗该疾病的潜在价值，值得进一步研究。
