Chang Sheng, Bai Yana, Pu Hongquan, Li Ni, Cheng Ning, Li Haiyan, Xie Zhidong, Li Fuxin, Hu Xiaobin, Zhu Jinbing, He Jie, Dai Min
Department of Cancer Prevention, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
Institute of Epidemiology and Biostatistics, School of Public Health, Center for Cancer Prevention and Control, Lanzhou University, Lanzhou 730000, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2016 Mar;37(3):325-8. doi: 10.3760/cma.j.issn.0254-6450.2016.03.006.
To evaluate the disease burden of colorectal cancer in Jinchang cohort, and provide evidence for preventing colorectal cancer and reducing the disease burden of colorectal cancer in the cohort.
The colorectal cancer mortality data from 2001 to 2013 and the medical records of colorectal cancer patients from 2001 to 2010 were collected for this retrospective cohort study. The colorectal cancer disease burden was described by using mortality rate, standardized mortality rate, medical expenditure, potential years of life lost (PYLL), average potential years of life lost (APYLL), working potential years of life lost (WPYLL), and average working potential years of life lost (AWPYLL). The development trend in disease burden of colorectal cancer was analyzed by using Spearman correlation and the average growth rate.
The crude mortality rate of colorectal cancer from 2001 to 2013 was 9.53/100,000 with the average annual growth rate of 12.89%. The PYLL, APYLL, WPYLL and AWPYLL of colorectal cancer were 485.00 person-years, 9.15 years, 253.00 person-years, and 4.77 years, respectively. The direct medical expenditure due to colorectal cancer was 7064.38 Yuan per case and 408.43 Yuan per day. There was no increasing trend in the direct medical expenditure due to colorectal cancer.
Colorectal cancer mortolity rate was on the rise and it caused heavy disease burden in Jinchang cohort.
评估金昌队列中结直肠癌的疾病负担，为该队列预防结直肠癌及降低结直肠癌疾病负担提供依据。
本回顾性队列研究收集了2001年至2013年的结直肠癌死亡率数据以及2001年至2010年结直肠癌患者的病历。采用死亡率、标准化死亡率、医疗费用、潜在寿命损失年数（PYLL）、平均潜在寿命损失年数（APYLL）、工作潜在寿命损失年数（WPYLL）和平均工作潜在寿命损失年数（AWPYLL）来描述结直肠癌的疾病负担。利用Spearman相关性和平均增长率分析结直肠癌疾病负担的发展趋势。
2001年至2013年结直肠癌的粗死亡率为9.53/10万，年均增长率为12.89%。结直肠癌的PYLL、APYLL、WPYLL和AWPYLL分别为485.00人年、9.15年、253.00人年和4.77年。结直肠癌的直接医疗费用为每例7064.38元，每天408.43元。结直肠癌的直接医疗费用没有上升趋势。
金昌队列中结直肠癌死亡率呈上升趋势，且造成了沉重的疾病负担。
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