Hewitt J, Walters M, Padmanabhan S, Dawson J
Department of Geriatric Medicine, Division of Population Medicine, Cardiff University, Cardiff, UK Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
BMJ Open. 2016 Mar 22;6(3):e009161. doi: 10.1136/bmjopen-2015-009161.
The UK Biobank is a large-scale biomedical resource, containing sociodemographic and medical information, including data on a previous diagnosis of stroke or transient ischaemic attack (TIA). We described these participants and their medication usage.
We identified participants who either self-reported or were identified from a nurse-led interview, having suffered a stroke or a TIA and compared them against participants without stroke ort TIA. We assessed their risk factor burden (sex, age, deprivation, waist to hip ratio (WHR), hypertension, smoking, alcohol intake, diabetes, physical exercise and oral contraception use (oral contraceptive pill, OCP)) and medication usage.
We studied 502,650 people (54.41% women), 6669 (1.23%) participants self-reported a stroke. The nurse-led interview identified 7669 (1.53%) people with stroke and 1781 (0.35%) with TIA. Hypertension, smoking, higher WHR, lower alcohol consumption and diabetes were all more common in people with cerebrovascular disease (p<0.0001 for each). Women with cerebrovascular disease were less likely to have taken the OCP (p=0.0002). People with cerebrovascular disease did more exercise (p=0.03). Antithrombotic medication was taken by 81% of people with stroke (both self-report and nurse-led responders) and 89% with TIA. For self-reported stroke, 63% were taking antithrombotic and cholesterol medications, 54% taking antithrombotic and antihypertensive medications and 46% taking all 3. For the nurse-led interview and TIA, these figures were 65%, 54% and 46%, and 70%, 53% and 45%, respectively.
The UK Biobank provides a large, generalisable and contemporary data source in a young population. The characterisation of the UK Biobank cohort with cerebrovascular disease will form the basis for ongoing research using this data source.
英国生物银行是一个大规模的生物医学资源库，包含社会人口统计学和医学信息，包括既往中风或短暂性脑缺血发作（TIA）的诊断数据。我们描述了这些参与者及其用药情况。
我们确定了那些自我报告或通过护士主导的访谈被确定曾患中风或TIA的参与者，并将他们与没有中风或TIA的参与者进行比较。我们评估了他们的危险因素负担（性别、年龄、贫困程度、腰臀比（WHR）、高血压、吸烟、饮酒量、糖尿病、体育锻炼和口服避孕药使用情况（口服避孕药，OCP））以及用药情况。
我们研究了502,650人（54.41%为女性），6669名（1.23%）参与者自我报告曾患中风。护士主导的访谈确定了7669名（1.53%）中风患者和1781名（0.35%）TIA患者。高血压、吸烟、较高的WHR、较低的饮酒量和糖尿病在脑血管疾病患者中更为常见（每项p<0.0001）。患有脑血管疾病的女性服用OCP的可能性较小（p = 0.0002）。患有脑血管疾病的人进行的锻炼更多（p = 0.03）。81%的中风患者（包括自我报告和护士主导访谈的应答者）以及89%的TIA患者服用抗血栓药物。对于自我报告的中风患者，63%服用抗血栓和胆固醇药物，54%服用抗血栓和抗高血压药物，46%服用所有三种药物。对于护士主导访谈的中风患者和TIA患者，这些数字分别为65%、54%和46%，以及70%%、53%和45%。
英国生物银行提供了一个针对年轻人群的大规模、可推广且具有时效性的数据源。对英国生物银行中脑血管疾病队列的特征描述将为使用该数据源的后续研究奠定基础。
