Chen Pan, Miah Mahfuzur Rahman, Aschner Michael
Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York, USA.
F1000Res. 2016 Mar 17;5. doi: 10.12688/f1000research.7431.1. eCollection 2016.
Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes. Damage caused by metal accumulation may result in permanent injuries, including severe neurological disorders. Epidemiological and clinical studies have shown a strong correlation between aberrant metal exposure and a number of neurological diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, autism spectrum disorders, Guillain-Barré disease, Gulf War syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and Wilson's disease. Here, we briefly survey the literature relating to the role of metals in neurodegeneration.
金属在人体中发挥着重要作用，维持细胞结构并调节基因表达、神经传递和抗氧化反应等。然而，神经系统中金属的过度积累可能具有毒性，会引发氧化应激、破坏线粒体功能并损害多种酶的活性。金属积累造成的损害可能导致永久性损伤，包括严重的神经紊乱。流行病学和临床研究表明，异常的金属暴露与多种神经疾病之间存在密切关联，这些疾病包括阿尔茨海默病、肌萎缩侧索硬化症、自闭症谱系障碍、格林-巴利综合征、海湾战争综合征、亨廷顿舞蹈症、多发性硬化症、帕金森病和威尔逊病。在此，我们简要综述与金属在神经退行性变中的作用相关的文献。
