从泰国旅行归来的旅行者经快速抗原检测呈阴性疟疾，分子诊断为 knowlesi 疟原虫。
Rapid-Antigen Test Negative Malaria in a Traveler Returning From Thailand, Molecularly Diagnosed as Plasmodium knowlesi.
机构信息
Ist Department of Medicine, Section of Tropical Medicine , University Medical Centre Eppendorf.
Bernhard Nocht Institute for Tropical Medicine , Hamburg , Germany.
出版信息
Open Forum Infect Dis. 2016 Mar 21;3(1):ofw039. doi: 10.1093/ofid/ofw039. eCollection 2016 Jan.
Plasmodium knowlesi has been identified in the last decade as a fifth species causing malaria in areas of South East Asia. Due to its short erythrocytic cycle, rapid development of high parasitemia and severe manifestations are frequently observed. Therefore, prompt diagnosis of infection is essential to prevent complications, but the low sensitivity of rapid diagnostic tests for P knowlesi pose a diagnostic challenge in acute settings. In this study, we report the case of a German traveler to Thailand, who was treated for P knowlesi malaria after returning to Germany. Rapid antigen test for malaria was negative on presentation. Diagnosis of a nonfalciparum malaria was made based on microscopy, and species definition was determined using polymerase chain reaction technique.
在过去的十年中，已知疟原虫 knowlesi 是导致东南亚地区疟疾的第五种病原体。由于其红细胞周期短，常观察到高寄生虫血症和严重表现迅速发展。因此，及时诊断感染对于预防并发症至关重要，但快速诊断检测对 P knowlesi 的低灵敏度在急性环境中构成了诊断挑战。在本研究中，我们报告了一名前往泰国的德国旅行者的病例，他在返回德国后因疟原虫 knowlesi 疟疾接受治疗。就诊时快速抗原检测疟疾呈阴性。根据显微镜检查做出非恶性疟原虫疟疾的诊断，并使用聚合酶链反应技术确定物种定义。
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