通过生物信息学分析确定2型糖尿病与重度抑郁症之间的遗传重叠。
Genetic overlap between type 2 diabetes and major depressive disorder identified by bioinformatics analysis.
作者信息
Ji Hong-Fang, Zhuang Qi-Shuai, Shen Liang
机构信息
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, P. R. China.
出版信息
Oncotarget. 2016 Apr 5;7(14):17410-4. doi: 10.18632/oncotarget.8202.
Abstract
Our study investigated the shared genetic etiology underlying type 2 diabetes (T2D) and major depressive disorder (MDD) by analyzing large-scale genome wide association studies statistics. A total of 496 shared SNPs associated with both T2D and MDD were identified at p-value ≤ 1.0E-07. Functional enrichment analysis showed that the enriched pathways pertained to immune responses (Fc gamma R-mediated phagocytosis, T cell and B cell receptors signaling), cell signaling (MAPK, Wnt signaling), lipid metabolism, and cancer associated pathways. The findings will have potential implications for future interventional studies of the two diseases.
摘要
我们的研究通过分析大规模全基因组关联研究统计数据，调查了2型糖尿病（T2D）和重度抑郁症（MDD）潜在的共同遗传病因。在p值≤1.0E - 07的情况下，共鉴定出496个与T2D和MDD均相关的单核苷酸多态性（SNP）。功能富集分析表明，富集的通路涉及免疫反应（FcγR介导的吞噬作用、T细胞和B细胞受体信号传导）、细胞信号传导（丝裂原活化蛋白激酶、Wnt信号传导）、脂质代谢以及癌症相关通路。这些发现将对这两种疾病未来的干预性研究具有潜在意义。
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