School of Chemistry, Cardiff University , Park Place, Cardiff CF10 3AT, U.K.
Department of Chemistry, KU Leuven , Celestijnen Laan 200F, B-3001 Heverlee, Belgium.
J Am Chem Soc. 2016 Apr 13;138(14):4695-705. doi: 10.1021/jacs.6b01761. Epub 2016 Apr 1.
Novel experimental techniques and computational methods have provided new insight into the behavior of reactive intermediates in solution. The results of these studies show that some of the earlier ideas about how reactive intermediates ought to behave in solution were incomplete or even incorrect. This Perspective summarizes the new experimental and computational methods and draws attention to the shortcomings that their application has brought to light in previous models. Key areas needing further research are highlighted.
新型实验技术和计算方法为我们理解反应中间体在溶液中的行为提供了新的视角。这些研究的结果表明，一些关于反应中间体在溶液中应该如何表现的早期观点是不完整的，甚至是错误的。本文总结了新的实验和计算方法，并提请注意它们在先前模型中的应用所揭示的缺陷。强调了需要进一步研究的关键领域。
