Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1049-001 Lisboa, Portugal.
iBB - Institute for Bioengineering and Biosciences and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1049-001, Lisboa, Portugal.
Dalton Trans. 2016 Apr 28;45(16):7114-23. doi: 10.1039/c6dt00099a.
Five new silver camphorimine complexes of general formula [Ag(NO3)(Y)L] were synthesized and fully characterized using spectroscopic and analytical techniques. The structure of [Ag(NO3)(OC10H14NC6H4NC10H14O)] () was analyzed using single crystal X-ray diffraction, showing that it arranges as a coordination polymer formed by sequential Ag(NO3) units bridged by the bi-camphor ligand (). The antimicrobial properties of the new complexes were screened using the disk diffusion method and their Minimal Inhibitory Concentrations (MIC) were assessed against selected bacterial strains of the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli, Pseudomonas aeruginosa, and Burkholderia contaminans. The lowest MICs were observed for , with estimated values of 72, 20, 32 and 19 μg mL(-1) for S. aureus, E. coli, B. contaminans, and P. aeruginosa, respectively. In the case of S. aureus, similar MIC values were obtained for silver nitrate and compound . All five compounds were bactericidal when used in concentrations equal or above the MIC value, as found by enumerating the total colony forming units (CFUs) after incubation in their presence.
五个新的银樟氮叶素配合物，通式为[Ag(NO3)(Y)L]，使用光谱和分析技术进行了全面的表征。配合物[Ag(NO3)(OC10H14NC6H4NC10H14O)]（）的结构通过单晶 X 射线衍射进行了分析，结果表明其排列为通过双樟氮叶素（）桥接的连续 Ag(NO3)单元形成的配位聚合物。采用圆盘扩散法对新配合物的抗菌性能进行了筛选，并评估了它们对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌、铜绿假单胞菌和鲍曼不动杆菌的最小抑菌浓度（MIC）。对于，观察到最低的 MIC 值，估计其对金黄色葡萄球菌、大肠杆菌、鲍曼不动杆菌和铜绿假单胞菌的 MIC 值分别为 72、20、32 和 19 μg mL(-1)。对于金黄色葡萄球菌，银硝酸盐和化合物的 MIC 值相似。在存在这些化合物的情况下，当使用浓度等于或高于 MIC 值时，所有五种化合物均具有杀菌作用，通过在其存在下孵育后计数总集落形成单位（CFU）来发现这一点。
