Costa Joana P, Sousa Sílvia A, Galvão Adelino M, Mata J Miguel, Leitão Jorge H, Carvalho M Fernanda N N
Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
IBB-Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Antibiotics (Basel). 2021 Jan 30;10(2):135. doi: 10.3390/antibiotics10020135.
Nine new complexes with camphor imine or camphor sulfonimine ligands were synthesized and analytically and spectroscopically characterized, aiming to identify the key parameters that drive the antibacterial activity of the complexes with metal cores and imine substituents with distinct electronic and steric characteristics. The antimicrobial activity of all complexes was evaluated by determining their minimum inhibitory concentrations (MIC) against the Gram-negative ATCC25922, 477, and IST408, and the Gram-positive Newman. Camphor imine complexes based on the hydroxyl silver center ({Ag(OH)}) typically perform better than those based on the nitrate silver center ({Ag(NO)}), while ligands prone to establish hydrogen bonding facilitate interactions with the bacterial cell surface structures. A different trend is observed for the silver camphor sulfonimine complexes that are almost non-sensitive to the nature of the metal cores {Ag(OH)} or {Ag(NO)} and display low sensitivity to the Y substituent. The antibacterial activities of the Ag(I) camphor sulfonimine complexes are higher than those of the camphor imine analogues. All the complexes display higher activity towards Gram-negative strains than towards the Gram-positive strain.
合成了九种带有樟脑亚胺或樟脑磺亚胺配体的新型配合物，并对其进行了分析和光谱表征，旨在确定驱动具有不同电子和空间特征的金属核与亚胺取代基配合物抗菌活性的关键参数。通过测定所有配合物对革兰氏阴性菌ATCC25922、477和IST408以及革兰氏阳性菌Newman的最低抑菌浓度（MIC）来评估其抗菌活性。基于羟基银中心（{Ag(OH)}）的樟脑亚胺配合物通常比基于硝酸银中心（{Ag(NO)}）的樟脑亚胺配合物表现更好，而易于形成氢键的配体有利于与细菌细胞表面结构相互作用。对于樟脑磺亚胺银配合物，观察到不同的趋势，它们对金属核{Ag(OH)}或{Ag(NO)}的性质几乎不敏感，并且对Y取代基表现出低敏感性。Ag(I)樟脑磺亚胺配合物的抗菌活性高于樟脑亚胺类似物。所有配合物对革兰氏阴性菌株的活性均高于对革兰氏阳性菌株的活性。
