Saini Isha, Kalaivani Mani, Kabra Sushil Kumar
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.
Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 110029, India.
Rheumatol Int. 2016 Jul;36(7):961-5. doi: 10.1007/s00296-016-3467-6. Epub 2016 Mar 23.
The aim was to retrospectively estimate the prevalence of calcinosis in patients with juvenile dermatomyositis (JDM) and to identify risk factors associated with development of calcinosis in these patients. Retrospective chart review of 39 children diagnosed with JDM between 2004 and 2015 in a tertiary care hospital was done. Patients were divided into two groups, depending on the presence or absence of calcinosis, and the two groups were compared with respect to demographic, clinical, laboratory and therapeutic characteristics. Calcinosis developed in nine (23.1 %) patients. Delay in diagnosis and initiation of treatment, prolonged duration of disease, the presence of joint contractures and cardiac involvement were significantly associated with increased frequency of calcinosis. Six out of nine (66.7 %) patients with calcinosis received alendronate therapy, out of which four showed partial reduction in calcinosis. In one case, surgical removal of tumorous clumps was done. Calcinosis remains a common complication of JDM. We found an association between calcinosis and delay in diagnosis and initiation of treatment, prolonged duration of disease and cardiac involvement. Our study suggests that alendronate may be beneficial in management of calcinosis of JDM.
本研究旨在回顾性评估幼年皮肌炎（JDM）患者中钙质沉着症的患病率，并确定与这些患者钙质沉着症发生相关的危险因素。对一家三级护理医院2004年至2015年间确诊为JDM的39名儿童进行了回顾性病历审查。根据是否存在钙质沉着症将患者分为两组，并比较两组在人口统计学、临床、实验室和治疗特征方面的差异。9名（23.1%）患者出现了钙质沉着症。诊断和开始治疗延迟、病程延长、存在关节挛缩和心脏受累与钙质沉着症发生率增加显著相关。9名有钙质沉着症的患者中有6名（66.7%）接受了阿仑膦酸盐治疗，其中4名患者的钙质沉着症有部分减轻。有1例患者进行了肿瘤团块的手术切除。钙质沉着症仍然是JDM的常见并发症。我们发现钙质沉着症与诊断和开始治疗延迟、病程延长及心脏受累之间存在关联。我们的研究表明，阿仑膦酸盐可能对JDM钙质沉着症的治疗有益。
