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[痛风的营养治疗]

[Nutritional therapy of gout].

作者信息

Nickolai Beate, Kiss Caroline

机构信息

1 Ernährungsberatung, Universitätsspital Basel.

出版信息

Ther Umsch. 2016;73(3):153-8. doi: 10.1024/0040-5930/a000772.

Abstract

Nutrition and nutritional behaviours have been found to play a major role in the development of gout. Studies show that body mass index (BMI), as well as excessive intake of alcoholic beverages, meat, soft drinks and fruit juices increase the risk of developing gout. Similarly, dairy products and coffee have been seen to decrease the risk of hyperuricemia and gout, as they increase the excretion of uric acid. Flares of gout are often caused by large meals and high alcohol consumption. Each additional intake of meat portion per day increases the risk of gout by 21 %. Taking total alcohol consumption into account, the risk of gout increases after one to two standard drinks. In contrast to previous assumptions purine-rich plant foods like legumes and vegetables do not increase the risk of gout. The current dietary guidelines take into account nutritional factors, which not only consider purine intake, but also their endogenous production and their influence on renal excretion. A balanced diet based on the Swiss healthy eating guideline pyramid as well as the Mediterranean diet is appropriate for this patient population. The treatment of gout is multi-faceted, since this patient population presents other comorbidities such as obesity, diabetes mellitus, dyslipidemia and hypertension. Collectively, these risk factors are diet dependent and require a treatment strategy that is centered on modifying one's nutrition and nutritional behaviours. The aim of such therapy is to educate the patient as well as treat the accompanying comorbidities with the goal of decreasing serum uric acid values. Motivated patients require consultation and follow-up care in order to be able to actively decrease the serum uric acid.

摘要

营养与营养行为在痛风的发病过程中起着重要作用。研究表明,体重指数(BMI)以及过量饮用酒精饮料、食用肉类、软饮料和果汁会增加患痛风的风险。同样,乳制品和咖啡可降低高尿酸血症和痛风的风险,因为它们能增加尿酸排泄。痛风发作通常由大餐和大量饮酒引起。每天每额外摄入一份肉类,患痛风的风险就会增加21%。考虑到总酒精摄入量,饮用一到两杯标准饮品后痛风风险会增加。与之前的假设相反,富含嘌呤的植物性食物,如豆类和蔬菜,不会增加痛风风险。当前的饮食指南考虑了营养因素,不仅考虑嘌呤摄入量,还考虑其内生生成及其对肾脏排泄的影响。基于瑞士健康饮食指南金字塔以及地中海饮食的均衡饮食适合这类患者群体。痛风的治疗是多方面的,因为这类患者群体还存在其他合并症,如肥胖、糖尿病、血脂异常和高血压。总体而言,这些风险因素与饮食有关,需要一种以改变营养和营养行为为中心的治疗策略。这种治疗的目的是教育患者并治疗伴随的合并症,以降低血清尿酸值。有积极性的患者需要咨询和后续护理,以便能够积极降低血清尿酸。

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