Manaloto C R, Hayes C G
US Naval Medical Research Unit, Manila, Philippines.
Southeast Asian J Trop Med Public Health. 1989 Dec;20(4):541-7.
Between 1983-1986, 336 strains of dengue virus were isolated from 1,911 patients who had been hospitalized with clinically suspected DF/DHF in Manila and nearby areas. Multiple serotypes were present every year. Although DEN 3 was the most common serotype isolated (40%) over the entire study period, DEN 2 and DEN 1 were more frequently isolated in 1983 and 1984, respectively. DEN 4 was consistently the least common serotype recovered. During 1984, geographic differences in the pattern of serotypes isolated were found for two heavily populated areas located only 70 km apart. A higher proportion of DEN 2 isolates were recovered from patients with gastrointestinal bleeding compared to DEN 1 and DEN 3. A higher proportion of DEN 1 and DEN 3 isolates came from patients experiencing a 1 degree infection compared to DEN 2, and the mean homologous HI antibody titer of the sera that DEN 2 was isolated from was significantly higher than the homologous titers of sera from which DEN 1 and DEN 3 were isolated.
1983年至1986年期间，从马尼拉及周边地区1911名临床疑似登革热/登革出血热而住院的患者中分离出336株登革病毒。每年都存在多种血清型。尽管在整个研究期间，DEN 3是分离出的最常见血清型（40%），但DEN 2和DEN 1分别在1983年和1984年更频繁地被分离出来。DEN 4一直是回收最少的血清型。1984年，在仅相距70公里的两个人口密集地区发现了分离出的血清型模式的地理差异。与DEN 1和DEN 3相比，从胃肠道出血患者中回收的DEN 2分离株比例更高。与DEN 2相比，DEN 1和DEN 3分离株中更高比例来自经历一度感染的患者，并且分离出DEN 2的血清的平均同源血凝抑制（HI）抗体滴度显著高于分离出DEN 1和DEN 3的血清的同源滴度。
