Yang Haichun, Fogo Agnes B, Kon Valentina
aDepartments of Pediatrics, Microbiology, and Immunology bDepartments of Medicine, Microbiology, and Immunology cDepartments of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Curr Opin Nephrol Hypertens. 2016 May;25(3):174-9. doi: 10.1097/MNH.0000000000000217.
The review will examine advances in our understanding of the role kidneys play in high-density lipoprotein (HDL) metabolism and the effect on levels, composition, and function of HDL particles.
Components of the HDL particles can cross the glomerular filtration barrier. Some of these components, including apolipoproteins and enzymes involved in lipid metabolism, are taken up by the proximal tubule and degraded, modified, salvaged/returned to the circulation, or lost in the urine. Injury of the glomerular capillaries or tubules can affect these intrarenal processes and modify HDL. Changes in the plasma and urine levels of HDL may be novel markers of kidney damage or mechanism(s) of kidney disease.
The kidneys have a significant role in the metabolism of individual HDL components, which in turn modulate HDL levels, composition, and functionality of HDL particles. These intrarenal effects may be useful markers of kidney damage and have consequences on kidney-related perturbations in HDL.
本综述将探讨我们对肾脏在高密度脂蛋白（HDL）代谢中所起作用的理解进展，以及对HDL颗粒水平、组成和功能的影响。
HDL颗粒的成分可穿过肾小球滤过屏障。其中一些成分，包括参与脂质代谢的载脂蛋白和酶，被近端小管摄取并降解、修饰、回收/返回循环或随尿液流失。肾小球毛细血管或肾小管的损伤会影响这些肾内过程并改变HDL。HDL血浆和尿液水平的变化可能是肾脏损伤或肾脏疾病机制的新标志物。
肾脏在单个HDL成分的代谢中起重要作用，进而调节HDL颗粒的水平、组成和功能。这些肾内效应可能是肾脏损伤的有用标志物，并对HDL中与肾脏相关的紊乱产生影响。
