Spaans Engelina A J M, van Dijk Peter R, Groenier Klaas H, Brand Paul L P, Reeser Maarten H, Bilo Henk J G, Kleefstra Nanne
J Pediatr Endocrinol Metab. 2016 Jun 1;29(6):657-61. doi: 10.1515/jpem-2015-0435.
The aim of this study was to investigate seasonality in the initial presentation of type 1 diabetes mellitus (T1DM) among Dutch children.
Observational, nationwide study in the Netherlands. Using the national registry for both healthcare reimbursement and pharmaceutical care, data of all Dutch children (aged 0-14 years) with a diagnosis of T1DM in the period 2009-2011 were obtained.
During the study period (2009-2011) an average annual number of 2.909.537 children aged 0-14 lived in the Netherlands and 676 children were diagnosed with T1DM per year, translating into an annual incidence rate (IR) of T1DM of 23.2 per hundred thousand children (ptc). The annual IR differed significantly (p=0.03) between seasons: 6.4 ptc in winter, 4.9 ptc in spring, 5.4 ptc in summer and 6.6 ptc in autumn. This pattern was present within both boys and girls Conclusions: Among Dutch children aged 0-14 years, there is seasonality in the of T1DM with a peak incidence in autumn and winter.
本研究旨在调查荷兰儿童1型糖尿病（T1DM）初发时的季节性情况。
在荷兰开展的一项全国性观察性研究。利用医疗报销和药物治疗的国家登记处，获取了2009年至2011年期间所有诊断为T1DM的荷兰儿童（0至14岁）的数据。
在研究期间（2009 - 2011年），荷兰平均每年有2909537名0至14岁儿童，每年有676名儿童被诊断为T1DM，T1DM的年发病率为每十万名儿童23.2例（ptc）。各季节的年发病率存在显著差异（p = 0.03）：冬季为6.4 ptc，春季为4.9 ptc，夏季为5.4 ptc，秋季为6.6 ptc。这种模式在男孩和女孩中均存在。结论：在0至14岁的荷兰儿童中，T1DM存在季节性，秋冬发病率最高。
