近端小管中的细胞旁钙转运与肾结石的形成
Paracellular calcium transport in the proximal tubule and the formation of kidney stones.
作者信息
Curry Joshua N, Yu Alan S L
机构信息
Department of Molecular and Integrative Physiology, University of Kansas Medical Center , Kansas City, Kansas.
Jared Grantham Kidney Institute, University of Kansas Medical Center , Kansas City, Kansas.
出版信息
Am J Physiol Renal Physiol. 2019 May 1;316(5):F966-F969. doi: 10.1152/ajprenal.00519.2018. Epub 2019 Mar 6.
Abstract
The proximal tubule (PT) is responsible for the majority of calcium reabsorption by the kidney. Most PT calcium transport appears to be passive, although the molecular facilitators have not been well established. Emerging evidence supports a major role for PT calcium transport in idiopathic hypercalciuria and the development of kidney stones. This review will cover recent developments in our understanding of PT calcium transport and the role of the PT in kidney stone formation.
摘要
近端小管（PT）负责肾脏对大部分钙的重吸收。尽管尚未明确其分子转运体，但大多数近端小管钙转运似乎是被动的。新出现的证据支持近端小管钙转运在特发性高钙尿症和肾结石形成过程中起主要作用。本综述将涵盖我们对近端小管钙转运的最新认识进展以及近端小管在肾结石形成中的作用。
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