用于光动力疗法的含硼二吡咯亚甲基纳米级金属有机框架材料。
BODIPY-containing nanoscale metal-organic frameworks for photodynamic therapy.
作者信息
Wang Weiqi, Wang Lei, Li Zhensheng, Xie Zhigang
机构信息
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
出版信息
Chem Commun (Camb). 2016 Apr 7;52(31):5402-5. doi: 10.1039/c6cc01048b.
BODIPY-immobilized zirconium-based nanoscale metal-organic frameworks (MOFs), named , have been synthesized through solvent-assisted ligand exchange using UiO-typed MOFs and pre-designed BODIPY ligands for the first time. The nanocrystal has been proved to possess good biocompatibility and highly efficient generation of singlet oxygen, which could kill the cancer cells effectively.
首次通过使用UiO型金属有机框架（MOF）和预先设计的硼二吡咯（BODIPY）配体的溶剂辅助配体交换，合成了固定有BODIPY的锆基纳米级金属有机框架（MOF），名为 。已证明该纳米晶体具有良好的生物相容性和高效的单线态氧生成能力，能够有效杀死癌细胞。
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