Hybrid Nanoplatforms Based on Photosensitizers and Metal/Covalent Organic Frameworks for Improved Cancer Synergistic Treatment Nano-Delivery Systems.

Researchers have extensively investigated photosensitizer (PS) derivatives for various applications due to their superior photophysical and electrochemical properties. However, inherent problems, such as instability and self-quenching under physiological conditions, limit their biological applications. Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) represent two relatively new material types. These materials have high surface areas and permanent porosity, and they show a tremendous deal of potential for applications like these. This review summarizes key synthesis processes and highlights recent advancements in integrating PS-based COF and MOF nanocarriers for biomedical applications while addressing potential obstacles and prospects.