Liang Xiaomeng, Dempski Robert E, Burdette Shawn C
Worcester Polytechnic Institute, Department of Chemistry and Biochemistry, Worcester, MA 01609-2280, United States.
Worcester Polytechnic Institute, Department of Chemistry and Biochemistry, Worcester, MA 01609-2280, United States.
Curr Opin Chem Biol. 2016 Apr;31:120-5. doi: 10.1016/j.cbpa.2016.02.008. Epub 2016 Mar 21.
Zinc is an essential micronutrient for cellular homeostasis. Initially proposed to only contribute to cellular viability through structural roles and non-redox catalysis, advances in quantifying changes in nM and pM quantities of Zn(2+) have elucidated increasing functions as an important signaling molecule. This includes Zn(2+)-mediated regulation of transcription factors and subsequent protein expression, storage and release of intracellular compartments of zinc quanta into the extracellular space which modulates plasma membrane protein function, as well as intracellular signaling pathways which contribute to the immune response. This review highlights some recent advances in our understanding of zinc signaling.
锌是细胞稳态所必需的微量营养素。最初认为锌仅通过结构作用和非氧化还原催化作用来维持细胞活力，但在对锌离子（Zn(2+)）纳摩尔和皮摩尔数量变化进行定量分析方面取得的进展，揭示了其作为重要信号分子的功能不断增加。这包括锌离子介导的转录因子调控以及随后的蛋白质表达、锌量子的细胞内区室向细胞外空间的储存和释放（这会调节质膜蛋白功能），还有参与免疫反应的细胞内信号通路。本综述重点介绍了我们在锌信号传导理解方面的一些最新进展。
