Aschenbroich Sophie A, Lafontaine Eric R, Hogan Robert J
a Department of Pathology , College of Veterinary Medicine, University of Georgia , Athens , GA , USA.
b Department of Infectious Diseases , College of Veterinary Medicine, University of Georgia , Athens , GA , USA.
Expert Rev Vaccines. 2016 Sep;15(9):1163-81. doi: 10.1586/14760584.2016.1170598. Epub 2016 Apr 20.
Burkholderia pseudomallei and Burkholderia mallei are pathogenic bacteria causing fatal infections in animals and humans. Both organisms are classified as Tier 1 Select Agents owing to their highly fatal nature, potential/prior use as bioweapons, severity of disease via respiratory exposure, intrinsic resistance to antibiotics, and lack of a current vaccine. Disease manifestations range from acute septicemia to chronic infection, wherein the facultative intracellular lifestyle of these organisms promotes persistence within a broad range of hosts. This ability to thrive intracellularly is thought to be related to exploitation of host immune response signaling pathways. There are currently considerable gaps in our understanding of the molecular strategies employed by these pathogens to modulate these pathways and evade intracellular killing. A better understanding of the specific molecular basis for dysregulation of host immune responses by these organisms will provide a stronger platform to identify novel vaccine targets and develop effective countermeasures.
类鼻疽伯克霍尔德菌和鼻疽伯克霍尔德菌是可在动物和人类中引发致命感染的病原菌。由于这两种微生物具有高度致命性、曾被用作生物武器的潜在/既往用途、经呼吸道暴露后的疾病严重性、对抗生素的固有耐药性以及目前缺乏疫苗，它们均被列为一级选择生物剂。疾病表现范围从急性败血症到慢性感染，其中这些微生物的兼性细胞内生活方式促使它们在广泛的宿主中持续存在。这种在细胞内茁壮成长的能力被认为与利用宿主免疫反应信号通路有关。目前，我们对这些病原体用于调节这些通路并逃避细胞内杀伤的分子策略的理解存在相当大的差距。更好地了解这些生物体失调宿主免疫反应的具体分子基础，将为识别新型疫苗靶点和开发有效对策提供更坚实的平台。
