Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Department of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
mSphere. 2019 Jan 2;4(1):e00674-18. doi: 10.1128/mSphere.00674-18.
and are the causative agents of melioidosis and glanders, respectively. There is no vaccine to protect against these highly pathogenic bacteria, and there is concern regarding their emergence as global public health () and biosecurity () threats. In this issue of , an article by Khakhum and colleagues (N. Khakhum, P. Bharaj, J. N. Myers, D. Tapia, et al., mSphere 4:e00570-18, 2019, https://doi.org/10.1128/mSphere.00570-18) describes a novel vaccination platform with excellent potential for cross-protection against both species. The report also highlights the importance of antibodies in immunity against these facultative intracellular organisms.
和 分别是类鼻疽和鼻疽的病原体。目前尚无针对这些高致病性细菌的疫苗，人们担心它们会成为全球公共卫生（）和生物安全（）威胁。在本期《mSphere》杂志上，Khakhum 等人（N. Khakhum、P. Bharaj、J. N. Myers、D. Tapia 等人，mSphere 4:e00570-18, 2019, https://doi.org/10.1128/mSphere.00570-18）描述了一种具有出色交叉保护两种 物种潜力的新型疫苗接种平台。该报告还强调了抗体在针对这些兼性细胞内生物的免疫中的重要性。
