在肝细胞癌模型中，通过原位形成植入物进行超声引导下阿霉素的瘤内递送。
Ultrasound-guided intratumoral delivery of doxorubicin from in situ forming implants in a hepatocellular carcinoma model.
作者信息
Solorio Luis, Wu Hanping, Hernandez Christopher, Gangolli Mihika, Exner Agata A
机构信息
Department of Chemical Engineering, University of Michigan, 2300 Hayward St, Ann Arbor, MI 48109, USA.
Case Center for Imaging Research, Department of Radiology, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106-5056, USA.
出版信息
Ther Deliv. 2016;7(4):201-12. doi: 10.4155/tde-2015-0008.
Abstract
BACKGROUND
Hepatocellular carcinomas are frequently nonresponsive to systemically delivered drugs. Local delivery provides an alternative to systemic administration, maximizing the dose delivered to the tumor, achieving sustained elevated concentrations of the drug, while minimizing systemic exposure.
RESULTS
Ultrasound-guided deposition of doxorubicin (Dox)-eluting in situ forming implants (ISFI) in an orthotopic tumor model significantly lowers systemic drug levels. As much as 60 µg Dox/g tumors were observed 21 days after ISFI injection. Tumors treated with Dox implants also showed a considerable reduction in progression at 21 days.
CONCLUSION
Dox-eluting ISFIs provide a promising platform for the treatment of hepatocellular carcinomas by which drug can be delivered directly into the lesion, bypassing distribution and elimination by the circulatory system.
摘要
背景
肝细胞癌通常对全身给药的药物无反应。局部给药是全身给药的一种替代方法，可使递送至肿瘤的剂量最大化，实现药物浓度持续升高，同时将全身暴露降至最低。
结果
在原位肿瘤模型中，超声引导下阿霉素（Dox）洗脱原位形成植入物（ISFI）的沉积显著降低了全身药物水平。ISFI注射后21天，观察到肿瘤中Dox含量高达60μg/g。用Dox植入物治疗的肿瘤在21天时进展也显著降低。
结论
Dox洗脱ISFI为肝细胞癌的治疗提供了一个有前景的平台，通过该平台药物可直接递送至病变部位，绕过循环系统的分布和消除。
相似文献
1
Ultrasound-guided intratumoral delivery of doxorubicin from in situ forming implants in a hepatocellular carcinoma model.在肝细胞癌模型中，通过原位形成植入物进行超声引导下阿霉素的瘤内递送。
Ther Deliv. 2016;7(4):201-12. doi: 10.4155/tde-2015-0008.
2
Effectiveness of localized ultrasound-targeted microbubble destruction with doxorubicin liposomes in H22 mouse hepatocellular carcinoma model.局部超声靶向微泡破坏联合阿霉素脂质体在H22小鼠肝癌模型中的有效性
J Drug Target. 2015 May;23(4):323-34. doi: 10.3109/1061186X.2014.996759. Epub 2015 Jan 22.
3
Doxorubicin-loaded poly(lactic-co-glycolic acid) microspheres prepared using the solid-in-oil-in-water method for the transarterial chemoembolization of a liver tumor.采用水包油包固法制备的载阿霉素聚乳酸-羟基乙酸共聚物微球用于肝肿瘤的经动脉化疗栓塞。
Colloids Surf B Biointerfaces. 2015 Aug 1;132:305-12. doi: 10.1016/j.colsurfb.2015.05.037. Epub 2015 May 27.
4
Doxorubicin-induced co-assembling nanomedicines with temperature-sensitive acidic polymer and their in-situ-forming hydrogels for intratumoral administration.多柔比星诱导的温度敏感酸性聚合物共组装纳米药物及其用于瘤内给药的原位形成水凝胶。
J Control Release. 2016 Aug 10;235:328-336. doi: 10.1016/j.jconrel.2016.06.009. Epub 2016 Jun 6.
5
Liquid-solid phase-inversion PLGA implant for the treatment of residual tumor tissue after HIFU ablation.用于治疗高强度聚焦超声（HIFU）消融后残留肿瘤组织的液-固相变聚乳酸-羟基乙酸共聚物（PLGA）植入物。
PLoS One. 2015 Feb 24;10(2):e0117358. doi: 10.1371/journal.pone.0117358. eCollection 2015.
6
Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice.脂质纳米粒共递送阿霉素和姜黄素增强治疗小鼠二乙基亚硝胺诱导的肝细胞癌
Eur J Pharm Biopharm. 2015 Jun;93:27-36. doi: 10.1016/j.ejpb.2015.03.003. Epub 2015 Mar 11.
7
Targeted hepatocellular carcinoma therapy: transferrin modified, self-assembled polymeric nanomedicine for co-delivery of cisplatin and doxorubicin.靶向肝细胞癌治疗：转铁蛋白修饰的自组装聚合物纳米药物用于顺铂和阿霉素的共递送
Drug Dev Ind Pharm. 2016 Oct;42(10):1590-9. doi: 10.3109/03639045.2016.1160103. Epub 2016 Mar 17.
8
Composition-property relationships for radiopaque composite materials: pre-loaded drug-eluting beads for transarterial chemoembolization.不透射线复合材料的组成-性能关系：用于经动脉化疗栓塞的预载药物洗脱微球
J Biomater Appl. 2015 Jul;30(1):93-103. doi: 10.1177/0885328215572196. Epub 2015 Feb 16.
9
Improved therapeutic effect of DOX-PLGA-PEG micelles decorated with bivalent fragment HAb18 F(ab')(2) for hepatocellular carcinoma.双价 HAb18 F(ab')(2)修饰的 DOX-PLGA-PEG 胶束提高了对肝癌的治疗效果。
Biomacromolecules. 2010 Sep 13;11(9):2422-31. doi: 10.1021/bm1005992.
10
Treatment of intermediate stage hepatocellular carcinoma: a review of intrahepatic doxorubicin drug-delivery systems.
Ther Deliv. 2014 Apr;5(4):447-66. doi: 10.4155/tde.14.11.
引用本文的文献
1
Synthesis and evaluation of cross-linked tragacanthin nanofibers as implants for delivery of cisplatin to hepatocellular carcinoma.交联黄芪胶纳米纤维作为顺铂递送植入物用于肝细胞癌治疗的合成与评价
Heliyon. 2024 Aug 31;10(17):e37304. doi: 10.1016/j.heliyon.2024.e37304. eCollection 2024 Sep 15.
2
Drug-Eluting Porous Embolic Microspheres for Trans-Arterial Delivery of Dual Synergistic Anticancer Therapy for the Treatment of Liver Cancer.载药多孔栓塞微球经动脉途径递送至肝癌的双重协同抗癌治疗。
Adv Healthc Mater. 2023 Dec;12(30):e2301548. doi: 10.1002/adhm.202301548. Epub 2023 Jun 26.
3
Integration of Real-Time Image Fusion in the Robotic-Assisted Treatment of Hepatocellular Carcinoma.实时图像融合在肝细胞癌机器人辅助治疗中的应用
Biology (Basel). 2020 Nov 12;9(11):397. doi: 10.3390/biology9110397.
4
Multimodality imaging-guided local injection of eccentric magnetic microcapsules with electromagnetically controlled drug release.多模态影像引导下经皮偏心磁微囊注射及电磁控制药物释放
Cancer Rep (Hoboken). 2019 Apr;2(2):e1154. doi: 10.1002/cnr2.1154. Epub 2018 Dec 21.
5
In situ forming implants exposed to ultrasound enhance therapeutic efficacy in subcutaneous murine tumors.超声暴露的原位形成植入物增强了皮下鼠肿瘤的治疗效果。
J Control Release. 2020 Aug 10;324:146-155. doi: 10.1016/j.jconrel.2020.05.003. Epub 2020 May 7.
6
Improving Treatment Efficacy of In Situ Forming Implants via Concurrent Delivery of Chemotherapeutic and Chemosensitizer.通过同时递送化疗药物和化学增敏剂来提高原位形成植入物的治疗效果。
Sci Rep. 2020 Apr 20;10(1):6587. doi: 10.1038/s41598-020-63636-x.
7
Local penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implants.通过肝内植入载多柔比星 PLGA 植入物实现多柔比星的局部渗透。
Drug Deliv. 2019 Dec;26(1):1049-1057. doi: 10.1080/10717544.2019.1676842.
8
Serum biomolecules unable to compete with drug refilling into cyclodextrin polymers regardless of the form.血清生物分子无论以何种形式都无法与重新填充到环糊精聚合物中的药物竞争。
J Mater Chem B. 2019 Sep 11;7(35):5320-5327. doi: 10.1039/c9tb00622b.
9
Increasing Distribution of Drugs Released from In Situ Forming PLGA Implants Using Therapeutic Ultrasound.利用治疗性超声增加原位形成的聚乳酸-羟基乙酸共聚物（PLGA）植入物释放药物的分布
Ann Biomed Eng. 2017 Dec;45(12):2879-2887. doi: 10.1007/s10439-017-1926-1. Epub 2017 Sep 19.
本文引用的文献
1
Image-guided therapies in the treatment of hepatocellular carcinoma: A multidisciplinary perspective.图像引导治疗在肝细胞癌治疗中的应用：多学科视角
World J Hepatol. 2015 Feb 27;7(2):235-44. doi: 10.4254/wjh.v7.i2.235.
2
Liquid-solid phase-inversion PLGA implant for the treatment of residual tumor tissue after HIFU ablation.用于治疗高强度聚焦超声（HIFU）消融后残留肿瘤组织的液-固相变聚乳酸-羟基乙酸共聚物（PLGA）植入物。
PLoS One. 2015 Feb 24;10(2):e0117358. doi: 10.1371/journal.pone.0117358. eCollection 2015.
3
Primary hepatocellular carcinoma and metabolic syndrome: An update.原发性肝细胞癌与代谢综合征：最新研究进展。
World J Gastrointest Oncol. 2013 Sep 15;5(9):186-94. doi: 10.4251/wjgo.v5.i9.186.
4
New progress of non-surgical treatments for hepatocellular carcinoma.肝细胞癌非手术治疗的新进展。
Med Oncol. 2013 Mar;30(1):381. doi: 10.1007/s12032-012-0381-y. Epub 2013 Jan 6.
5
Noninvasive characterization of the effect of varying PLGA molecular weight blends on in situ forming implant behavior using ultrasound imaging.采用超声成像技术无创性分析不同 PLGA 分子量混合物对原位形成植入物行为的影响。
Theranostics. 2012;2(11):1064-77. doi: 10.7150/thno.4181. Epub 2012 Nov 8.
6
Advances in image-guided intratumoral drug delivery techniques.影像引导下瘤内药物递送技术的进展。
Ther Deliv. 2010 Aug;1(2):307-22. doi: 10.4155/tde.10.20.
7
Effect of cargo properties on in situ forming implant behavior determined by noninvasive ultrasound imaging.非侵入性超声成像对原位形成植入物行为的货物特性影响。
Drug Deliv Transl Res. 2012 Feb 1;2(1):45-55. doi: 10.1007/s13346-011-0054-y.
8
The effect of nanoparticle size, shape, and surface chemistry on biological systems.纳米颗粒的大小、形状和表面化学性质对生物系统的影响。
Annu Rev Biomed Eng. 2012;14:1-16. doi: 10.1146/annurev-bioeng-071811-150124. Epub 2012 Apr 18.
9
Cisplatin tumor biodistribution and efficacy after intratumoral injection of a biodegradable extended release implant.瘤内注射可生物降解缓释植入物后顺铂的肿瘤生物分布及疗效
Chemother Res Pract. 2011;2011:175054. doi: 10.1155/2011/175054. Epub 2011 Feb 27.
10
Folate-decorated maleilated pullulan-doxorubicin conjugate for active tumor-targeted drug delivery.叶酸修饰的马来酰化普鲁兰-阿霉素偶联物用于主动肿瘤靶向药物递送。
Eur J Pharm Sci. 2011 Apr 18;42(5):517-26. doi: 10.1016/j.ejps.2011.02.006. Epub 2011 Feb 23.
Zotero 插件