Islam Md Ashraful, El-Dahiyat Faris, Nouri Ahmed, Alefan Qais, Naqvi Atta Abbas
Department of Pharmacy Practice, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Clinical Pharmacy Program, College of Pharmacy, Al Ain University, Al Ain, United Arab Emirates.
Front Pharmacol. 2023 Sep 20;14:1194672. doi: 10.3389/fphar.2023.1194672. eCollection 2023.
Medication adherence is a major challenge for patients with diabetes. Adherence rates are often low, and this can lead to poor glycaemic control and increased risk of complications. There are a number of tools available to measure medication adherence, but few have been validated in Arabic-speaking populations. This study aimed to validate the Arabic version of the General Medication Adherence Scale in patients with type 2 diabetes in Jordan. A cross-sectional study was conducted for 3 months among patients attending diabetes mellitus outpatient clinic in Irbid, Jordan. The validation procedure included confirmatory factor analysis (CFA) and equation modelling (SEM). Fit indices, namely, goodness of fit index (GFI), Tucker Lewis index (TLI), comparative fit index (CFI), and root mean square error of approximation (RMSEA) were observed. Corrected item-total correlation (ITC) was reported. Reliability was assessed using Cronbach's alpha (α) and α value based on item deletion was also carried out. Intraclass correlation coefficient (ICC) was reported. Data were analyzed using IBM SPSS v23 and IBM AMOS v25. Data from 119 participants were gathered. The mean adherence score was 27.5 (±6) ranging from 6 to 33. More than half of the patients were adherent to their therapy (n = 79, 66.4%). The reliability of the scale (n = 11) was 0.907, and ICC ranged from 0.880-0.930: 95% CI. The following values were observed in CFA; χ = 62.158, df = 41, χ/df = 1.516, GFI = 0.913, AGFI = 0.860, TLI = 0.960, CFI = 0.971 and RMSEA = 0.066. A total of 10 out of 11 items had corrected ITC >0.5. The α remained between 0.89-0.92 during item deletion. The results obtained in this study suggest that the scale is valid and reliable in measuring adherence to medications in the studied sample of patients with diabetes. This scale can be used by clinicians in Jordan to assess adherence and may further aide in evaluating interventions to improve adherence rates in persons with type 2 diabetes.
药物依从性是糖尿病患者面临的一项重大挑战。依从率往往较低，这可能导致血糖控制不佳，并增加并发症风险。有多种工具可用于衡量药物依从性，但在讲阿拉伯语的人群中经过验证的却很少。本研究旨在验证约旦2型糖尿病患者通用药物依从性量表的阿拉伯语版本。在约旦伊尔比德糖尿病门诊就诊的患者中进行了为期3个月的横断面研究。验证程序包括验证性因子分析（CFA）和方程建模（SEM）。观察了拟合指数，即拟合优度指数（GFI）、塔克·刘易斯指数（TLI）、比较拟合指数（CFI）和近似均方根误差（RMSEA）。报告了校正后的项目-总分相关性（ITC）。使用克朗巴赫α系数（α）评估信度，并基于项目删除进行α值计算。报告了组内相关系数（ICC）。使用IBM SPSS v23和IBM AMOS v25对数据进行分析。收集了119名参与者的数据。平均依从性得分为27.5（±6），范围为6至33。超过一半的患者坚持治疗（n = 79，66.4%）。该量表（n = 11）的信度为0.907，ICC范围为0.880 - 至0.930（95%置信区间）。在CFA中观察到以下值：χ = 62.158，df = 41，χ/df = 1.516，GFI = 0.913，AGFI = 0.860，TLI = 0.960，CFI = 0.971，RMSEA = 0.066。11个项目中有10个校正后的ITC>0.5。在项目删除过程中，α值保持在0.89 - 0.92之间。本研究获得的结果表明，该量表在测量所研究的糖尿病患者样本的药物依从性方面是有效且可靠的。约旦的临床医生可使用该量表评估依从性，并可能进一步有助于评估改善2型糖尿病患者依从率的干预措施。
