5-HT4-mediated neuroprotection: a new therapeutic modality on the way?
作者信息
Gershon Michael D
机构信息
Department of Pathology and Cell Biology, Columbia University, New York, New York
出版信息
Am J Physiol Gastrointest Liver Physiol. 2016 May 15;310(10):G766-7. doi: 10.1152/ajpgi.00120.2016. Epub 2016 Mar 24.
Abstract
摘要
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本文引用的文献
1
Prucalopride exerts neuroprotection in human enteric neurons.普芦卡必利对人肠神经元具有神经保护作用。
Am J Physiol Gastrointest Liver Physiol. 2016 May 15;310(10):G768-75. doi: 10.1152/ajpgi.00036.2016. Epub 2016 Feb 18.
2
Enteric glia mediate neuron death in colitis through purinergic pathways that require connexin-43 and nitric oxide.肠胶质细胞通过需要连接蛋白43和一氧化氮的嘌呤能途径介导结肠炎中的神经元死亡。
Cell Mol Gastroenterol Hepatol. 2016 Jan 1;2(1):77-91. doi: 10.1016/j.jcmgh.2015.08.007.
3
Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense.血清素是肠道的一把剑和一面盾：血清素兼具攻击和防御作用。
Trans Am Clin Climatol Assoc. 2012;123:268-80; discussion 280.
4
5-Hydroxytryptamine (serotonin) in the gastrointestinal tract.胃肠道中的 5-羟色胺（血清素）。
Curr Opin Endocrinol Diabetes Obes. 2013 Feb;20(1):14-21. doi: 10.1097/MED.0b013e32835bc703.
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Neuronal serotonin regulates growth of the intestinal mucosa in mice.神经元血清素调节小鼠肠道黏膜的生长。
Gastroenterology. 2012 Aug;143(2):408-17.e2. doi: 10.1053/j.gastro.2012.05.007. Epub 2012 May 15.
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Nat Med. 2012 Mar 18;18(4):600-4. doi: 10.1038/nm.2679.
7
Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.激活结肠黏膜 5-HT(4)受体可加速推进性运动并抑制内脏敏感性。
Gastroenterology. 2012 Apr;142(4):844-854.e4. doi: 10.1053/j.gastro.2011.12.041. Epub 2012 Jan 4.
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Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons.肠神经元 5-羟色胺在胃肠动力中的基本作用和肠多巴胺能神经元的发育/存活。
J Neurosci. 2011 Jun 15;31(24):8998-9009. doi: 10.1523/JNEUROSCI.6684-10.2011.
9
Serotonin has a key role in pathogenesis of experimental colitis.血清素在实验性结肠炎的发病机制中起关键作用。
Gastroenterology. 2009 Nov;137(5):1649-60. doi: 10.1053/j.gastro.2009.08.041. Epub 2009 Aug 23.
10
5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice.5-羟色胺4受体介导的成年小鼠肠神经系统中的神经保护和神经发生
J Neurosci. 2009 Aug 5;29(31):9683-99. doi: 10.1523/JNEUROSCI.1145-09.2009.
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